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The EOSC-Life consortium publishes an article in the EMBO Journal, outlining effective measures to boost the utilization and sustainability of data resources. The study also presents twelve recommendations for handling research data in alignment with FAIR principles.
Biomedcode’s Tg197 human TNF transgenic mouse model of chronic destructive arthritis provides new insights on how combination treatment with Dasatinib and low-dose anti-TNF leads to synergistic senolytic effects on chondrocytes and effective treatment of arthritis.
A Biomedcode collaboration has developed a human-RANKL dependent breast cancer mouse model aiming to study disease mechanisms and establish preclinical platforms for the evaluation of human therapeutics targeting cancer.
A study conducted by the German Mouse Clinic and collaborating research institutions reveals a previously unknown connection between the DHX9 gene and various rare neurodevelopmental disorders.
A new publication of INFRAFRONTIER in Mammalian Genome is available on line now. Get an overview of the latest INFRAFRONTIER advancements, including services, resources, and technical developments.
New research identified an endogenous factor influencing amyloid pathology in Alzheimer’s disease using the APPPS1-21 mouse model. The study opens doors to novel polymorphism-based interventions.
Mouse models are relevant to study the functionality of genes involved in human diseases; however, translation of phenotypes can be challenging. This paper identified 153 genes associated with heart disease in humans, 151 with a one-to-one mouse ortholog.