Home / News
The 20th anniversary of the ICS (Institut Clinique de la Souris) coincides with the 20th anniversary of the sequencing of the mouse genome!
This recently published translational study sheds light on the UQCRH gene and mitochondrial complex III diseases. An international team led by researchers and clinicians from Helmholtz Zentrum München, Germany, Manchester Centre for Genomic Medicine, UK, Newcastle University, UK and University Hospital Salzburg, Austria, identified two cousins with a deletion in the UQCRH gene, which codes for a structural complex III subunit, and characterized a novel mouse model that carries the equivalent deletion in Uqcrh.
In this current study scientists teamed up to unraveled the mechanistic cascade underlying cortical spreading depression (CSD) and migraine susceptibility exemplified in a mouse model of familial hemiplegic migraine type 3 (FHM3).
Influenza during pregnancy increases the susceptibility to infection in offspring In this recent study, scientists of the Heinrich-Pette-Institute, Hamburg, and the University of Veterinary Medicine Hannover together with colleagues from the Helmholtz Zentrum München, the Imperial College London, and the Research Center Borstel could show, that moderate influenza A infection of pregnant mice increased the offspring’s susceptibility to infection from other viruses as well as bacteria, especially early in life. Enhanced vulnerability to infection in neonates was associated with reduced haematopoetic development and immune responses.
Virtual mindmap shows the way through a diverse network of research options for Rare Diseases
The European Joint Programme on Rare Diseases (EJP RD), coordinating 130 institutions from 35 countries, is the largest international network of activities to fight the more than 7,000 known rare diseases. Launched by the European Commission in 2019, the programme´s vital goal is to create a comprehensive, sustainable European and worldwide “rare diseases ecosystem” – allowing a virtuous circle between research, care and medical innovation.
Scientists from the University of Bonn in collaboration with colleagues from Radboud University, Nijmegen and the German Mouse Clinic showed, that Creld1, the first single gene linked to atrioventricular septal defects (AVSD) of newborn, regulates myocardial development and function in mice.
On 22 February 2021, thirty universities, research organizations and biomedical companies in France signed the “French transparency charter on the use of animals for scientific and regulatory purposes”
A new EBRA cluster will coordinate the predictive use of animal models in brain research
The European Union and its member states have been investing in research to better understand the human brain and its disorders for many years.
The International Mouse Phenotyping Consortium has announced the election of a new Senior Leadership Team (SLT): Radislav Sedlácek is the new Chairman of IMPC, and Yann Herault the new Vice-Chair. Steve Brown, who was the Chair for many years, has stepped down to become the Past Chair. All three of them are long-term members of IMPC as well as INFRAFRONTIER.
As part of the International Mouse Phenotyping Consortium (IMPC), researchers from Helmholtz Zentrum München led by Prof. Hrabě de Angelis, have uncovered a large number of novel genes controlling the mineral density of bone. Because bone mineral density is low in patients with osteoporosis, these findings will help to better understand the underlying molecular mechanisms of the disease. The new insight is important to advance precision medicine for people affected by osteoporosis in terms of prevention and therapeutic options.
In a common effort, scientists of the German Mouse Clinic and Turku University examined the immune system of genetically modified mice that develop high estrogen levels in males. Applying in vivo and molecular phenotyping approaches, the researchers showed that an imbalanced circulating estrogen to androgen ratio in male mice feminized their immune response. Furthermore, their B cell function was altered, and the risk of autoimmune diseases was enhanced. The study was published recently in Scientific Reports.
Using a combination of in vitro and in vivo screens, scientists from the Helmholtz-Zentrum München and colleagues identified the RNA-modifying enzyme METTL6 as a potential new oncogene. In line with findings that loss of METTL6 inhibits liver cancer cell proliferation and impaired colony formation capacity, low expression of METTL6 correlates with increased survival of patients with hepatocellular carcinoma.
By funding £20 million into a new National Mouse Genetics Network, the British Medical Research Council (MRC) acknowledges the critical importance of the mouse as an experimental model. The Mary Lyon Centre (MLC) in Harwell will serve as the national facility hub of the new network.
Lydia Teboul from INFRAFRONTIER partner MRC Harwell has been awarded the 3Rs Prize 2020 of the International Society for Transgenic Technologies (ISTT). The prize recognises Lydia’s work in developing a new technique to reduce the number of animals used in research.
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is the neuronal isoform of ITPKs and exhibits both actin bundling and InsP3kinase activity. In addition to neurons, ITPKA is ectopically expressed in tumor cells, where its oncogenic activity increases tumor cell malignancy. This raise the question, if inhibition of ITPKA could reduce oncogenic activity. However, prior to developing ITPKA specific inhibitors for treatment of cancer patients, it has to be excluded that ITPKA exhibits essential functions in non-tumor cells.
An international team of researchers lead by Helmholtz Zentrum München uncovered the molecular mechanisms that link rRNA methylation to development and disease. The study was published in “Genes & Development”.
Munich / Salt Lake City – The role for iron in the pathogenesis of diabetes is on debate. While the consequences of excess iron in β-cell function and survival are established, the effects of iron deficiency on β-cell function and diabetes risk in humans are not yet fully understood.
In the INFRAFRONTIER2020 specialised phenotyping program, INFRAFRONTIER partner institutions offer the indepth characterisation of mouse mutants for interested biomedical researchers all around the globe. The call is free of charge for the user, concerning scientific service and expertise.
Munich / Stockholm – Karolinska Institutet, one of the world´s leading medical universities selecting the Nobel Prize laureates in Physiology or Medicine every year, is now a co-owner of INFRAFRONTIER GmbH.
It´s a unique training event for of all kinds of biomedial scientists working with mouse models – held in a fascinating location: The bi-annually organized European Advanced School for Mouse Phenogenomics, taking place on 20 to 24 May 2019 near Strasbourg, offers an overview of up-to-date methods and good practices for the use of mouse models in scientific research that cannot be found anywhere else in Europe.
“The application of artificial intelligence is the next big step to discover new ground in our massive biomedical data sets. We have to make use of this disruptive technology now”, says Prof. Dr. Martin Hrabĕ de Angelis, director at the Helmholtz Center Munich and coordinator of the pan-European project “INFRAFRONTIER”.
GV-SOLAS, the German Society for Laboratory Animal Research, is Europe´s oldest and largest association of animal research experts of all kind –scientists, veterinary doctors, animal keepers, and operators of animal facilities. Its annual meeting 2018 was held on 12 to 14 September in Munich.
In its second Open Call CORBEL (Coordinated Research Infrastructures Building Enduring Life-science services ) invites researchers from the biomedical field to apply to access technologies and services offered by more than 20 facilities from 10 different research infrastructures (RIs) across Europe, including INFRAFRONTIER.
The human microbiome and its immense impact on the health conditions of the human body has become a vital topic in international biomedical research – as shown lately in a interesting article in the British daily The Guardian.
In 2018, two big European meetings co-organized by INFRAFRONTIER will cover the role of animal research for studying the microbiome:
In a new Trans-national Access Call INFRAFRONTIER offers open access to its infrastructure and expertise for researchers who need rat mutant models to be generated for their scientific aims. It’s the first time that the European research infrastructure for modeling human diseases via mammalian genomes expands its unique services to generate not only mouse, but rat models for its users.
Health Data Research UK will invest £30 million in a newly developed big data approach for health and biomedical informations from all over the country. Starting in April 2018, only six sites in the UK with high-class expertise in the management of health data will be part of the new public venture.
A new multi-organ disease named FINCA (Fibrosis, Neurodegeneration and Cerebral Angiomatosis) that is fatal in early childhood has been identified in three pediatric patients in Finland. Children affected have previously undescribed formation of connective tissue in the lungs, neurodegeneration and increased vasculature formation in the brain.
Scientists have identified a network of genes that could play a vital role in the development of metabolic diseases such as diabetes
Two major papers from the International Mouse Phenotyping Consortium have been published today in Nature Genetics and Nature Communications.
The RItrain Project, launched a unique international management development programme.
The Jackson Laboratory is delivering a hands-on mouse surgery workshop at UPMC in Paris, France.
CORBEL – Coordinated Research Infrastructures Building Enduring Life-science services – is an EC Horizon2020 project uniting 11 Biological and Medical Science Research Infrastructures (RIs). In CORBEL, the participating RIs expand their cooperation in order to harmonise researchers’ access to their cutting-edge technologies and services by establishing a sustainable platform of aligned services that will enable faster admission to and a wider portfolio of technologies and services to boost research projects.
Roughly a third of all genes in the mammalian genome are essential for life. A new article in Nature, from an international, multi-institutional research team including many INFRAFRONTIER partners, describes the large-scale discovery of those genes and how it will impact understanding of mammalian development and human disease.
INFRAFRONTIER service charges will be changing as of 01 August 2016. New pricing will be posted and take effect as of 01 August 2016.
We will honor previously quoted rates for registrations of interest (ROI) and projects with ongoing services initiated prior to 01 August. Projects initiated after 01 August will be quoted and billed with the new rates.
The next issue of the Journal ‘Mammalian Genome’ will be dedicated to the study of ageing and age-related diseases. It contains an overview article on INFRAFRONTIER as a European resource for studying the functional basis of human disease. The article highlights the platforms and resources that INFRAFRONTIER provides for ageing research, an more generally how INFRAFRONTIER promotes the global sharing of high-quality resources and data and thus contributes to data reproducibility and animal welfare.
Scientists at Helmholtz Zentrum München (HMGU), in collaboration with the Technical University of Munich (TUM) and the German Center for Diabetes Research (DZD), have shown that diet-induced obesity and diabetes can be epigenetically inherited by the offspring via both the oocytes and the sperm.
The results were published in Nature Genetics and have received broad international media attention.
The European Strategy Forum on Research Infrastructures (ESFRI) officially launched its Roadmap 2016 Report on an event held in Amsterdam on 10 March 2016 organised under the Dutch EU Presidency.
The Report lists 29 “ESFRI Landmarks”, one of them is INFRAFRONTIER. ESFRI Landmarks are research infrastructures that were implemented or started implementation before 2015 and are now considered “major elements of competitiveness of the European Research Area”.
GEMM-ESC protocol published in EMBO Molecular Medicine last year, the Netherlands Cancer Institute (NKI) presented a strategy for rapid analysis of gene function in mouse models by deriving and modifying embryonic stem cells (ESC) from validated genetically engineered mouse models (GEMM), the so-called GEMM-ESC strategy.
INFRAFRONTIER is partner in two new Horizon 2020 projects that started on 01 September: CORBEL and RItrain.
CORBEL brings together the ESFRI Biological and Medical Research Infrastructures (BMS RI) to develop common services and harmonised access procedures to facilitate groundbreaking interdisciplinary research in the area of the life sciences. Together, the BMS RI cover the entire range from the discovery of basic biological mechanisms to applied medical translation.
Mutant mouse strains generated and phenotyped by the International Mouse Phenotyping Consortium are made available to the research community via public repositories, mostly as cryopreserved sperm or embryos. To ensure the quality of this frozen resource there is a requirement that for each strain the frozen sperm/embryos are proven able to produce viable mutant progeny, before the live animal resource is removed from cages.
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. This consortium developped new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power.
Reproducibility: Use mouse biobanks or lose them, Nature | Comment 10 June 2015 Kent Lloyd, Craig Franklin, Cat Lutz & Terry Magnuson Now that genetic engineering of mice is so easy, centralized repositories are essential, argue Kent Lloyd and colleagues.
The IPAD-MD project, Research Infrastructures for Phenotyping, Archiving and Distribution of Mouse Diseases Models, will address the coordination and cooperation between INFRAFRONTIER and complementary research infrastructures world-wide contributing to the global effort of IMPC, has been funded under the EC Horizon 2020 Programme.
EURORDIS, the alliance of European patient organisations for rare diseases, campains for a European Year on Rare Diseases 2019. This should raise awareness for the 30 million Europeans who suffer from a rare disease and encourage research that focuses on these rare, mostly unknown, seriously debilitating and often life-threatening diseases.
INFRAFRONTIER, provider of resources and services for rare diseases research, strongly supports the EURORDIS campaign.
A publication describing the INFRAFRONTIER service portfolio and the web portal that gives access to all of them has been accepted for the next Database Issue of Nucleic Acids Research. Advance access is available on the NAR webpage.
The management system of German Mouse Clinic has been successfully audited and certified by TÜV SÜD according to the Quality Management System Standards EN ISO 9001: 2008.
Reproducibility and traceability of analytical data, documentation, transparency and continuity are the cornerstones of the German Mouse Clinic quality management system. The certification reflects the German Mouse Clinic commitment to promote research activities at the highest level in science and scientific standards.
Cryoport, Inc. the only end-to-end cryogenic logistics solutions provider, entered into an agreement with the European Mouse Mutant Archive (EMMA), a part of INFRAFRONTIER, the European Research Infrastructure for phenotyping and archiving of model mammalian genomes
enOway guarantees freedom to operate (FTO) and offers important time gain in conditional knockout development time for industry scientists.
From 20 to 24 October 2014 the CNR Monterotondo and The Jackson Laboratory offer a comprehensive course on cryopreservation of mouse embryos, sperm and ovaries. The course is financially supported by the EC FP7 Capacities Specific Program through the INFRAFRONTIER-I3 project.
The INFRAFRONTIER IMPC workshop: Promoting the international exchange of mouse mutant resources, took place in Munich, Germany, 08-09 May 2014.
The main objectives of the workshop were to discuss how to simplify the international exchange of mouse mutant resources and to define the procedural changes to achieve it, to review the key issues facing the mouse community and mouse repositories as well as focus on IP issues and to present best practices in sharing research tools
The INFRAFRONTIER IMPC Phenotyping Workshop took place in San Francisco, California, USA, 19 – 20 March 2014, attracting the participation of around 60 international delegates.
The main aims of the Phenotyping Workshop were to assess tests, progress and phenotype detection, as well as to discuss the test implementation for IMPC Phase II.
The Phenotyping Workshop was funded through the INFRAFRONTIER InfraCoMP Project.
Second phenotyping call of the EC FP7 funded INFRAFRONTIER-I3 project open until March 15, 2014.
A total of 22 mouse mutant lines can be characterised through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.
The course is intended to give animal technologists hands-on experience of the murine embryo and spermatozoa freezing techniques routinely used at Harwell. In addition, delegates will gain experience of a simple and robust in vitro fertilization procedure.
In a formal act authenticated by a notary in Munich, four founding members acquired shares of the INFRAFRONTIER GmbH: the Centre National de la Recherche Scientifique (CNRS) from France, the Biomedical Sciences Research Center ‘Alexander Fleming’ from Greece, the Institute of Molecular Genetics of the Acedemy of Sciences of the Czech Republic, and the University of Oulu in Finland.
On 02 to 04 December, INFRAFRONTIER holds an international workshop in Rome, together with the International Mouse Phenotyping Consortium (IMPC) and the International Knockout Mouse Konsortium (IKMC). More than 200 participants will participate.
The aim of the Rome meeting is to discuss how researchers from different scientific fields and from industry can benefit from the large-scale mouse genomics initiatives INFRAFRONTIER, the IMPC and the IKMC, and to obtain feedback from the research community on future needs and improvements.
The meeting is funded through the EC-funded projects InfraCoMP and EUCOMTOOLS, the Italian National Research Council (CNR) generously provides the meeting venue.
The aim of this INFRAFRONTIER training course held from 20 to 22 Novembeer 2013 at the Universitat Autònoma de Barcelona (UAB), Spain is capacitating participants to localize and to interpret the most common skeletal morphological abnormalities found in mutant mice. This will occur in the context of dedicated learning sessions devoted to the study of bone anatomy and the methodologies (X-ray, CT, Alizarin staining, etc) used to visualize the mouse skeleton. Each lecture will be followed by a practical session in which participants will work with real bone specimens and CT images.
From 21 to 25 October 2013 the CNR Monterotondo and The Jackson Laboratory offer a comprehensive course on cryopreservation of mouse embryos, sperm and ovaries. The course is financially supported by the EC FP7 Capacities Specific Program through the INFRAFRONTIER-I3 project.
FP7 funded INFRAFRONTIER-I3 project (2013-2016) supports eligible customers with a free of charge mouse production service implemented as a Transnational Access (TA) activity providing a total of 30 access units. The access unit is defined by the production of a minimum of two heterozygous mice carrying the targeted gene allele of choice from the corresponding validated gene-targeted ES cell clone(s).
INFRAFRONTIER project was included in a selection of ESFRI projects, currently in implementation phase, to feature in the ESFRI brochure on ‘European Research Infrastructures with global impact’, published for the 10th anniversary of ESFRI. With the publication of this brochure, ESFRI intents to make the general public more broadly aware of the ESFRI itself and of the goals of the different ESFRI Research Infrastructures.