IMPC phenotypes (gene matching)
B6.129-Camk4tm1Gsc/Ieg
| Status | Available to order |
| EMMA ID | EM:02126 |
| International strain name | B6.129-Camk4tm1Gsc/Ieg |
| Alternative name | CaMKIV flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Camk4tm1Gsc |
| Gene/Transgene symbol | Camk4 |
Information from provider
| Provider | Günther Schütz |
| Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
| Genetic information | Exon 3 of the Camk4 gene was flanked by loxP sites. |
| Phenotypic information | None. |
| Breeding history | More than 5 generations of C57BL/6N backcross. Mice will be kept in backcross breeding. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- tremors / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- abnormal female reproductive system morphology / MGI
- abnormal ovarian follicle morphology / MGI
- absent corpus luteum / MGI
- abnormal male reproductive system morphology / MGI
- seminiferous tubule degeneration / MGI
- arrest of spermatogenesis / MGI
- decreased body weight / MGI
- decreased anxiety-related response / MGI
- ataxia / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- reduced long term depression / MGI
- limb grasping / MGI
- abnormal reproductive system physiology / MGI
- reduced female fertility / MGI
- male infertility / MGI
- abnormal gametogenesis / MGI
- abnormal spermiogenesis / MGI
- decreased litter size / MGI
- decreased chemically-elicited antinociception / MGI
- abnormal learning/memory/conditioning / MGI
- premature death / MGI
- abnormal reproductive system morphology / MGI
- no abnormal phenotype detected / MGI
- oligozoospermia / MGI
- decreased vertical activity / MGI
- abnormal excitatory postsynaptic currents / MGI
- abnormal synaptic depression / MGI
- abnormal inhibitory postsynaptic currents / MGI
- abnormal bone remodeling / MGI
- abnormal locomotor activation / MGI
- nervous system phenotype / MGI
- decreased testis weight / MGI
- decreased male germ cell number / MGI
- abnormal behavior / MGI
- decreased osteoclast cell number / MGI
- homeostasis/metabolism phenotype / MGI
- behavior/neurological phenotype / MGI
- teratozoospermia / MGI
- abnormal spermatid morphology / MGI
- abnormal osteoclast differentiation / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- anovulation / MGI
- abnormal sperm flagellum morphology / MGI
- abnormal sperm head morphology / MGI
- polyovular ovarian follicle / MGI
- impaired contextual conditioning behavior / MGI
- impaired cued conditioning behavior / MGI
- impaired conditioned place preference behavior / MGI
- increased bone volume / MGI
Literature references
- Conditional mutagenesis of CamKIV.;Casanova Emilie, Fehsenfeld Sandra, Greiner Erich, Stewart Andrew Francis, Schütz Günther, ;2002;Genesis (New York, N.Y. : 2000);32;161-4; 11857809