MGI phenotypes (allele matching)
B6.129X1-Csrp2tm1Rawe/Ieg
| Status | Available to order |
| EMMA ID | EM:01784 |
| International strain name | B6.129X1-Csrp2tm1Rawe/Ieg |
| Alternative name | CSRP2 ko |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Csrp2tm1Rawe, |
| Gene/Transgene symbol | Csrp2 |
Information from provider
| Provider | Ralf Weiskirchen |
| Provider affiliation | RWTH University Hospital Aachen |
| Genetic information | The Csrp2 gene contains six exons coding for a protein of approximately 21 KDa molecular weight. A neomycin resistance cassette was inserted into exon 4 at nucleotide 7292 via homologous recombination. |
| Phenotypic information | Slight defect of heart function and architecture. In this regard it resembles the Csrp3/MLP knock-out mouse. |
| Breeding history | The strain was backcrossed (N10) and is homozygous for the knock-out construct. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.;Sagave Julia F, Moser Markus, Ehler Elisabeth, Weiskirchen Sabine, Stoll Doris, Günther Kalle, Büttner Reinhard, Weiskirchen Ralf, ;2008;BMC developmental biology;8;80; 18713466
- The cysteine-rich protein family of highly related LIM domain proteins.;Weiskirchen R, Pino J D, Macalma T, Bister K, Beckerle M C, ;1995;The Journal of biological chemistry;270;28946-54; 7499425