C57BL/6N-Tg(Th-SNCA*)15Ccs/Ieg
| Status | Available to order |
| EMMA ID | EM:14608 |
| International strain name | C57BL/6N-Tg(Th-SNCA*)15Ccs/Ieg |
| Alternative name | C57BL/6N-Tg(Th-Snca15Hlu) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Th-SNCA*)1.2Ccs, |
| Gene/Transgene symbol | Tg(Th-SNCA*)1.2Ccs |
Information from provider
| Provider | Xinran Zhu |
| Provider affiliation | Tierphysiologie, Biologie, Ruhr-Universität Bochum |
| Genetic information | Th-Snca transgenic mice express the human α-synuclein gene with two missense mutations (A53T and A30P) under the direction of the mouse tyrosine hydroxylase promoter. |
| Phenotypic information | Homozygous:Transgenic mice were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron (DA) numbers in the substantia nigra and fiber densities and dopamine levels in the striatum were normal. Accumulation of damaged mitochondrion were observed in DA neurons and in glia cells within the region as well.Heterozygous:Transgenic mice were viable, fertile, and showed no gross anatomical or neuronal abnormalities. |
| Breeding history | The construct was microinjected into fertilized C57BL/6N oocytes and the founder line 15 were bred to C57BL/6N to establish the colony. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N |
Literature references
- Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage.;Stichel Christine C, Zhu Xin-Ran, Bader Verian, Linnartz Bettina, Schmidt Saskia, Lübbert Hermann, ;2007;Human molecular genetics;16;2377-93; 17412759
- Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria.;Schmidt Saskia, Linnartz Bettina, Mendritzki Sonja, Sczepan Teresa, Lübbert Matthias, Stichel Christine C, Lübbert Hermann, ;2011;Human molecular genetics;20;1197-211; 21212098
- Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice.;Maskri Lyutha, Zhu XinRan, Fritzen Sabrina, Kühn Kati, Ullmer Christoph, Engels Peter, Andriske Michael, Stichel Christine C, Lübbert Hermann, ;2004;Neuro-degenerative diseases;1;255-65; 16908976