EMMA Strains for Pox Virus Research

The European Mouse Mutant Archive (EMMA) distributes various strains carrying mutations of genes involved in “abnormal susceptibility to Poxviridae infection” that are also among those in MGI’s current listing of involved genes/alleles/phenotypes.

Gene

EMMA Strain(s)

Type

Agbl5

EM:13907, C57BL/6N-Agbl5<em1(IMPC)Wtsi>/WtsiCnbc

CRISPR/Cas-mediated constitutive KO

Aim2

EM:12693, C57BL/6NCrl-Aim2<em1(IMPC)Ccpcz/Ph

CRISPR/Cas-mediated constitutive KO

Cgas

EM:07632, C57BL/6NTac-Cgas<tm1a(EUCOMM)Hmgu>/IcsOrl

ES-cell targeted conditional KO

Ifnar1

EM:10181, C57BL/6N-A Ifnar1<tm2a(EUCOMM)Wtsi>/WtsiOulu

ES-cell targeted conditional KO

Il6

EM:13231, B6.Cg-Il6<tm2.1Jho>/Cnbc

ES-cell targeted KO

Il15

EM:07964, C57BL/6N-Il15<tm1a(EUCOMM)Hmgu>/H

ES-cell targeted conditional KO-first

Irf1

EM:05519, B6Dnk;B6Brd;B6N-Tyr Irf1<tm1a(EUCOMM)Wtsi>/WtsiOulu

ES-cell targeted conditional KO

Lta/Tnf

EM:01780 and EM: 00130, B6.129-Lta/Tnft/Orl

ES-cell targeted constitutive KO

Pik3cg

EM:05431, STOCK Pik3cg<tm1a(EUCOMM)Wtsi>/WtsiOulu

ES-cell targeted conditional KO

See further details at MGI page with abnormal susceptibility to Poxviridae infection and “Phenotype and Disease information” section on respective EMMA public strain’s descriptions