| Status | Available to order |
| EMMA ID | EM:00130 |
| Citation information | RRID:IMSR_EM:00130 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Lta/Tnftm1Fda/Orl |
| Alternative name | LT-a TNF-a |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lta/Tnftm1Fda |
| Gene/Transgene symbol | Lta |
| Provider | F Dautry |
| Provider affiliation | c/o CDTA-Orleans |
| Phenotypic information | Mutant mice deficient in lymphotoxin A (Lta or LT-alpha) and tumor necrosis factors (Tnf or TNF-alpha) genes, by homologous recombination (insertion of neo gene with deletion of all the Lta gene and a part of the Tnf gene). The tumor necrosis factors (TNF and LTA) are important mediators of the immune and inflammatory responses. The heterozygous mice have 20- to 100-fold lower TNF levels in circulation than the wild-type mice. Moreover, the heterozygous animals have an increased bacterial load following Listeria monocytogenes infection. |
| Breeding history | R1 ES cells (129/Sv); chimaeras crossed to C57BL/6 and then intercrossed. |
| References |
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| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
