MGI phenotypes (allele matching)
B6.129P2-Anp32atm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07238 |
| International strain name | B6.129P2-Anp32atm1Mak/Cnbc |
| Alternative name | Anp32a (Anp32a |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Anp32atm1Mak |
| Gene/Transgene symbol | Anp32a |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | The targeting construct replaces the entire coding region (2 exons) with PGKneo gene in the reverse orientation. |
| Phenotypic information | On the basis of previous analyses of mice bearing targeted mutations of Anp32a or Anp32e, there has been speculation that all ANP32 proteins play redundant roles and are dispensable for normal development. However, more recent work has suggested that ANP32B may in fact have functions that are not shared by other ANP32 family members. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
Literature references
- Generation and characterization of the Anp32e-deficient mouse.;Reilly Patrick T, Afzal Samia, Wakeham Andrew, Haight Jillian, You-Ten Annick, Zaugg Kathrin, Dembowy Joanna, Young Ashley, Mak Tak W, ;2010;PloS one;5;e13597; 21049064
- Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development.;Reilly Patrick T, Afzal Samia, Gorrini Chiara, Lui Koren, Bukhman Yury V, Wakeham Andrew, Haight Jillian, Ling Teo Wei, Cheung Carol C, Elia Andrew J, Turner Patricia V, Mak Tak Wah, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;10243-8; 21636789
- ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response.;Beck Sebastian, Zickler Martin, Pinho Dos Reis Vinícius, Günther Thomas, Grundhoff Adam, Reilly Patrick T, Mak Tak W, Stanelle-Bertram Stephanie, Gabriel Gülşah, ;2020;Frontiers in immunology;11;450; 32231671