B6.129P2-Malt1tm1Mak/Cnbc

Status

Available to order

EMMA IDEM:06391
International strain nameB6.129P2-Malt1tm1Mak/Cnbc
Alternative nameMalt1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolMalt1tm1Mak
Gene/Transgene symbolMalt1

Information from provider

ProviderTak W Mak
Provider affiliationMak Lab, Campbell Family Breast Cancer reseach Institute
Genetic informationDeletion of exon 8 with the neo targeting vector in antisense.
Phenotypic informationMalt1 is essential for T cell activation, proliferation, and IL-2 production in response to TCR ligation and strictly required for signal-specific NF-kappaB activation induced by the TCR, but not TNF-alpha or IL-1 signaling.
Breeding historyBackcrossed 10 times to C57BL/6.
References
  • Differential requirement for Malt1 in T and B cell antigen receptor signaling.;Ruland Jürgen, Duncan Gordon S, Wakeham Andrew, Mak Tak W, ;2003;Immunity;19;749-58; 14614861
  • The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.;Brüstle Anne, Brenner Dirk, Knobbe Christiane B, Lang Philipp A, Virtanen Carl, Hershenfield Brian M, Reardon Colin, Lacher Sonja M, Ruland Jürgen, Ohashi Pamela S, Mak Tak W, ;2012;The Journal of clinical investigation;122;4698-709; 23114599
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6J

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal immune system morphology / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal double-negative T cell morphology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal T cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • absent B-1a cells / MGI
  • decreased interleukin-2 secretion / MGI
  • impaired humoral immune response / MGI

Literature references

  • Differential requirement for Malt1 in T and B cell antigen receptor signaling.;Ruland Jürgen, Duncan Gordon S, Wakeham Andrew, Mak Tak W, ;2003;Immunity;19;749-58; 14614861
  • The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.;Brüstle Anne, Brenner Dirk, Knobbe Christiane B, Lang Philipp A, Virtanen Carl, Hershenfield Brian M, Reardon Colin, Lacher Sonja M, Ruland Jürgen, Ohashi Pamela S, Mak Tak W, ;2012;The Journal of clinical investigation;122;4698-709; 23114599

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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