MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6.129S2-Synbtm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:06348 |
| International strain name | B6.129S2-Synbtm1.1Ics/Ics |
| Alternative name | Syncytin-B conditional KO |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Synbtm1.1Ics, |
| Gene/Transgene symbol | Synb |
Information from provider
| Provider | Thierry Heidmann |
| Provider affiliation | UMR8122 CNRS, Institut Gustavec Roussy |
| Genetic information | In the targeting vector, the syncytin-B ORF and its surrounding sequences were amplified from 129/Sv mouse DNA by PCR. The targeted allele contains the unique syncytin-B ORF flanked by loxP recombination sites allowing its conditional excision. |
| Phenotypic information | Mice with conditional allele: no obvious phenotypic defects. Mice with syncytin-B knock-out allele (after cre-mediated excision of syncytin-B ORF): homozygous null embryos display an impaired placentation, with late-onset growth retardation and reduced neonate number. |
| Breeding history | Backcrossed 5 times to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
| Animals used for archiving | heterozygous 0, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.;Dupressoir Anne, Vernochet Cécile, Harper Francis, Guégan Justine, Dessen Philippe, Pierron Gérard, Heidmann Thierry, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;E1164-73; 22032925