IMPC phenotypes (gene matching)
STOCK Pawrtm1Jmos/Cnbc
| Status | Available to order |
| EMMA ID | EM:06218 |
| International strain name | STOCK Pawrtm1Jmos/Cnbc |
| Alternative name | Pawr |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pawrtm1Jmos |
| Gene/Transgene symbol | Pawr |
Information from provider
| Provider | Manuel Serrano |
| Provider affiliation | Molecular Oncology, CNIO (Spanish National Cancer Research Centre) |
| Genetic information | Exons 1 and 2 were replaced with a neomycin resistance gene. Embryonic fibroblasts derived from mice homozygous for this allele did not express the protein. |
| Phenotypic information | Decreased apoptosis. Increased B and T cell proliferation. Increased lymphocyte cell number. Enlarged spleen. Spleen hyperplasia. |
| Breeding history | Chimeras were crossed with CD1 females. Heterozygous offspring were crossed among themselves to generate homozygous mutants. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.), wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) |
| Stage of embryos | Morula |
Disease and phenotype information
MGI phenotypes (gene matching)
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- no abnormal phenotype detected / MGI
- behavioral despair / MGI
- increased lymphocyte cell number / MGI
- increased B cell proliferation / MGI
- increased T cell proliferation / MGI
- behavior/neurological phenotype / MGI
- abnormal T-helper 2 physiology / MGI
- decreased sensitivity to induced cell death / MGI
Literature references
- Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38.;Garcia-Cao Isabel, Lafuente María José, Criado Luis M, Diaz-Meco María Teresa, Serrano Manuel, Moscat Jorge, ;2003;EMBO reports;4;307-12; 12634851
- Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.;Fernandez-Marcos Pablo J, Abu-Baker Shadi, Joshi Jayashree, Galvez Anita, Castilla Elias A, Cañamero Marta, Collado Manuel, Saez Carmen, Moreno-Bueno Gema, Palacios Jose, Leitges Michael, Serrano Manuel, Moscat Jorge, Diaz-Meco Maria T, ;2009;Proceedings of the National Academy of Sciences of the United States of America;106;12962-7; 19470463
- Nephrin deficiency activates NF-kappaB and promotes glomerular injury.;Hussain Sagair, Romio Leile, Saleem Moin, Mathieson Peter, Serrano Manuel, Moscat Jorge, Diaz-Meco Maria, Scambler Peter, Koziell Ania, ;2009;Journal of the American Society of Nephrology : JASN;20;1733-43; 19497968
- Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.;Joshi Jayashree, Fernandez-Marcos Pablo J, Galvez Anita, Amanchy Ramars, Linares Juan F, Duran Angeles, Pathrose Peterson, Leitges Michael, Cañamero Marta, Collado Manuel, Salas Clara, Serrano Manuel, Moscat Jorge, Diaz-Meco Maria T, ;2008;The EMBO journal;27;2181-93; 18650932
- Tumour-suppression activity of the proapoptotic regulator Par4.;García-Cao Isabel, Duran Angeles, Collado Manuel, Carrascosa Maria J, Martín-Caballero Juan, Flores Juana M, Diaz-Meco Maria T, Moscat Jorge, Serrano Manuel, ;2005;EMBO reports;6;577-83; 15877079
- Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.;Durán Angeles, Rodriguez Angelina, Martin Pilar, Serrano Manuel, Flores Juana Maria, Leitges Michael, Diaz-Meco María T, Moscat Jorge, ;2004;The EMBO journal;23;4595-605; 15526032
- Regulation of mature T lymphocyte proliferation and differentiation by Par-4.;Lafuente María José, Martin Pilar, Garcia-Cao Isabel, Diaz-Meco María Teresa, Serrano Manuel, Moscat Jorge, ;2003;The EMBO journal;22;4689-98; 12970181