MGI phenotypes (allele matching)
- decreased fibroblast cell migration / MGI
B6.129-Mrc2tm1Cmi/H
| Status | Available to order |
| EMMA ID | EM:04674 |
| International strain name | B6.129-Mrc2tm1Cmi/H |
| Alternative name | Endo180ΔEx2-6/Endo180ΔEx2-6: C57BL/6 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mrc2tm1Cmi |
| Gene/Transgene symbol | Mrc2 |
Information from provider
| Provider | Clare Isacke |
| Provider affiliation | Institute of Cancer Research |
| Genetic information | Exons 2-6 of the Endo180 (Mrc2) gene were replaced with a PGK-neo cassette. The deleted region includes the N-terminal cysteine-rich domain, the FNII domain and the first C-type lectin-like domain. A truncated transmembrane protein defective in collagen binding is produced but is less stable that the wild-type receptor and is barely detected in the adult animal. |
| Phenotypic information | Homozygous Endo180-DeltaEx2-6/Endo180-DeltaEx2-6 mice are phenotypically normal (at the gross level), healthy and fertile. |
| Breeding history | C57BL/6.129/Sv Endo180-DeltaEx2-6/Endo180-DeltaEx2-6 mice were backcrossed onto C57BL/6 for 7 generations. The strain is currently maintained on C57BL/6. This strain is maintained by mating two homozygous carriers. Expected coat color from breeding: Black. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6 |
| Breeding at archiving centre | No breeding was carried out at the archiving centre. |
Disease and phenotype information
Literature references
- A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake.;East Lucy, McCarthy Afshan, Wienke Dirk, Sturge Justin, Ashworth Alan, Isacke Clare M, ;2003;EMBO reports;4;710-6; 12835757