IMPC phenotypes (gene matching)
B6;129-Nod2tm1.1Kuv/Orl
| Status | Available to order |
| EMMA ID | EM:04317 |
| International strain name | B6;129-Nod2tm1.1Kuv/Orl |
| Alternative name | B6.129Sv/Pas-Nod2tm |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nod2tm1.1Kuv |
| Gene/Transgene symbol | Nod2 |
Information from provider
| Provider | Philip ROSENSTIEL |
| Provider affiliation | IKMB, University of Kiel |
| Genetic information | Deletion of the translation start by insertion of two loxP sites flanking exons 2 and 3 and breeding with Cre-Deleter. Details available upon request. |
| Phenotypic information | Not known. |
| Breeding history | Backcrossed to C57BL/6 for less than 5 generations. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous , wild-type C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Blau syndrome / Orphanet_90340
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- abnormal immune system morphology / MGI
- abnormal Peyer's patch morphology / MGI
- weight loss / MGI
- abnormal immune system physiology / MGI
- altered susceptibility to infection / MGI
- impaired macrophage phagocytosis / MGI
- decreased IgG level / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal macrophage morphology / MGI
- abnormal macrophage physiology / MGI
- impaired neutrophil phagocytosis / MGI
- abnormal cytokine secretion / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal response to infection / MGI
- increased double-negative T cell number / MGI
- abnormal T-helper 1 physiology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased Peyer's patch number / MGI
- enlarged Peyer's patches / MGI
- abnormal autophagy / MGI
- increased susceptibility to induced colitis / MGI
- increased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- increased circulating interferon-gamma level / MGI
- increased circulating interleukin-2 level / MGI
- increased interleukin-1 beta secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- decreased susceptibility to endotoxin shock / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI