MGI phenotypes (allele matching)
B6;129P2-Grm5tm1Dgen/H
| Status | Available to order |
| EMMA ID | EM:02359 |
| International strain name | B6;129P2-Grm5tm1Dgen/H |
| Alternative name | DELTAGEN_T797 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Grm5tm1Dgen |
| Gene/Transgene symbol | Grm5 |
Information from provider
| Provider | Deltagen Inc. |
| Provider affiliation | Deltagen Inc. |
| Phenotypic information | Densitometry: fat percent and total tissue mass, low, homozygous females and males, 300 days. Necropsy: body weights, low, homozygous females, 49 days, and homozygous females and males, 300 days. Aging metrics: tendency for low body weight, and low body weight to body length ratio, homozygous females and males. Behavior: Homozygous mutants were impaired on the Rotarod test. Homozygous mutants were significantly different than wild-type control mice on the Metrazol test. Homozygous mutants displayed an increased response latency trend during acute thermal pain tests. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- abnormal cued conditioning behavior / MGI
- abnormal spatial learning / MGI
- abnormal contextual conditioning behavior / MGI
- reduced long term potentiation / MGI
- abnormal motor coordination/balance / MGI
- increased thermal nociceptive threshold / MGI
- abnormal cocaine consumption / MGI
- abnormal nociception after inflammation / MGI
- decreased susceptibility to pharmacologically induced seizures / MGI
- increased susceptibility to pharmacologically induced seizures / MGI
- abnormal excitatory postsynaptic potential / MGI
- abnormal locomotor activation / MGI
- abnormal nerve fiber response / MGI
- decreased alcohol consumption / MGI
- behavior/neurological phenotype / MGI
- abnormal latent inhibition of conditioning behavior / MGI
- impaired behavioral response to cocaine / MGI
- decreased total body fat amount / MGI
- abnormal inhibitory learning / MGI