B6;129S5-Trpm1tm1Lex/Orl

Status

Available to order

EMMA IDEM:02332
International strain nameB6;129S5-Trpm1tm1Lex/Orl
Alternative nameLEXKO-428
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTrpm1tm1Lex
Gene/Transgene symbolTrpm1

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationThe homozygous mutant mice exhibited decreased body temperature and impaired glucose tolerance when compared with their wild-type littermates and the historical means. Disruption of the target gene was confirmed by Southern hybridization analysis.
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • mydriasis / IMPC
  • impaired pupillary reflex / IMPC
  • increased circulating creatine kinase level / IMPC
  • limb grasping / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • impaired glucose tolerance / IMPC
MGI phenotypes (allele matching)
  • abnormal vision / MGI
  • abnormal rod electrophysiology / MGI
  • abnormal cone electrophysiology / MGI
  • abnormal eye physiology / MGI
  • abnormal eye electrophysiology / MGI
MGI phenotypes (gene matching)
  • abnormal vision / MGI
  • abnormal channel response / MGI
  • abnormal rod electrophysiology / MGI
  • abnormal cone electrophysiology / MGI
  • abnormal eye physiology / MGI
  • vision/eye phenotype / MGI
  • abnormal eye electrophysiology / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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