IMPC phenotypes (gene matching)
B6;129P2-Bace2tm1Bdes/Ieg
| Status | Available to order |
| EMMA ID | EM:02029 |
| International strain name | B6;129P2-Bace2tm1Bdes/Ieg |
| Alternative name | Bace 2 C/C |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Bace2tm1Bdes |
| Gene/Transgene symbol | Bace2 |
Information from provider
| Provider | Bart De Stropper |
| Provider affiliation | Flanders interuniversitary institute for biotechnologies (VIB) |
| Genetic information | Two loxP sites were first introduced in the Bace2 introns flanking the exon 6, which contains one of the two active sites of the enzyme. Mice heterozygous for the Bace2 conditional targeted allele were subsequently crossed with mice expressing cre recombinase from the ubiquitous phosphoglycerate kinase promoter, resulting in the deletion of Bace2 exon 6. |
| Phenotypic information | None. |
| Breeding history | The colony is maintained without any backcrossing. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
- abnormal cell physiology / MGI
Literature references
- Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.;Dominguez Diana, Tournoy Jos, Hartmann Dieter, Huth Tobias, Cryns Kim, Deforce Siska, Serneels Lutgarde, Camacho Ira Espuny, Marjaux Els, Craessaerts Katleen, Roebroek Anton J M, Schwake Michael, D'Hooge Rudi, Bach Patricia, Kalinke Ulrich, Moechars Dieder, Alzheimer Christian, Reiss Karina, Saftig Paul, De Strooper Bart, ;2005;The Journal of biological chemistry;280;30797-806; 15987683