C57BL/6-Tg(Fabp1-NTN1)6Mhln/Orl
| Status | Available to order |
| EMMA ID | EM:01980 |
| International strain name | C57BL/6-Tg(Fabp1-NTN1)6Mhln/Orl |
| Alternative name | Tg6-netrin-1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Fabp1-NTN1)6Mhln, |
| Gene/Transgene symbol | Tg(Fabp1-NTN1)6Mhln |
Information from provider
| Provider | Patrick Mehlen |
| Provider affiliation | CNRS FRE2870 |
| Genetic information | The transgene contains chick netrin 1 cDNA under the gut-specific Fabpl (Fabp1) promoter. |
| Phenotypic information | Decrease of apoptotic cells in the intestinal epithelia. Spontaneous formation of hyperplastic and neoplastic lesions in gastrointestinal tract. Occasional polycystic kidney. |
| Breeding history | Animals are currently being maintained as hemizygotes by matings with C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Literature references
- Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.;Mazelin Laetitia, Bernet Agnès, Bonod-Bidaud Christelle, Pays Laurent, Arnaud Ségolène, Gespach Christian, Bredesen Dale E, Scoazec Jean-Yves, Mehlen Patrick, ;2004;Nature;431;80-4; 15343335
- Netrin-1 Overexpression Induces Polycystic Kidney Disease: A Novel Mechanism Contributing to Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.;Mohamed Riyaz, Liu Yang, Kistler Andreas D, Harris Peter C, Thangaraju Muthusamy, ;2022;The American journal of pathology;192;862-875; 35358475