B6.Cg-Tolliptm1Kbns/Cnrm

Status

Available to order

EMMA IDEM:01970
International strain nameB6.Cg-Tolliptm1Kbns/Cnrm
Alternative nameC57BL/6-TgH(Tollip)23Siec
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTolliptm1Kbns
Gene/Transgene symbolTollip

Information from provider

ProviderJurg TSCHOPP
Provider affiliationDepartement de Biochimie-Université de Lausanne
Genetic informationThe targeting vector was generated by replacing a 11.5 Kb genomic fragment, encoding the N-terminal region of Tollip, with a neomycin cassette.
Phenotypic informationDefective inflammatory responses such as reduced cytokines production.
References
  • Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.;Didierlaurent Arnaud, Brissoni Brian, Velin Dominique, Aebi Natalia, Tardivel Aubry, Käslin Edgar, Sirard Jean Claude, Angelov Georgi, Tschopp Jürg, Burns Kimberly, ;2006;Molecular and cellular biology;26;735-42; 16428431

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased tumor necrosis factor secretion / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased interleukin-6 secretion / MGI
MGI phenotypes (gene matching)
  • decreased tumor necrosis factor secretion / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased interleukin-6 secretion / MGI

Literature references

  • Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.;Didierlaurent Arnaud, Brissoni Brian, Velin Dominique, Aebi Natalia, Tardivel Aubry, Käslin Edgar, Sirard Jean Claude, Angelov Georgi, Tschopp Jürg, Burns Kimberly, ;2006;Molecular and cellular biology;26;735-42; 16428431
  • Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice.;Liu Yi, Jiang Xiao-Li, Liu Yu, Jiang Ding-Sheng, Zhang Yan, Zhang Rui, Chen Yingjie, Yang Qinglin, Zhang Xiao-Dong, Fan Guo-Chang, Li Hongliang, ;2014;Cardiovascular research;101;87-96; 24285748
  • Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia-Reperfusion Injury in Mice.;Yan Zhen-Zhen, Huang Yong-Ping, Wang Xin, Wang Hai-Ping, Ren Fei, Tian Rui-Feng, Cheng Xu, Cai Jie, Zhang Yan, Zhu Xue-Yong, She Zhi-Gang, Zhang Xiao-Jing, Huang Zan, Li Hongliang, ;2019;Hepatology (Baltimore, Md.);70;1750-1769; 31077413
  • Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis.;Wan Nian, Liu Xiaoxiong, Zhang Xiao-Jing, Zhao Yichao, Hu Gangying, Wan Fengwei, Zhang Rui, Zhu Xueyong, Xia Hao, Li Hongliang, ;2015;British journal of pharmacology;172;3383-96; 25765712

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).