B6.Cg-Tolliptm1Kbns/Cnrm
Status | Available to order |
EMMA ID | EM:01970 |
International strain name | B6.Cg-Tolliptm1Kbns/Cnrm |
Alternative name | C57BL/6-TgH(Tollip)23Siec |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tolliptm1Kbns |
Gene/Transgene symbol | Tollip |
Information from provider
Provider | Jurg TSCHOPP |
Provider affiliation | Departement de Biochimie-Université de Lausanne |
Genetic information | The targeting vector was generated by replacing a 11.5 Kb genomic fragment, encoding the N-terminal region of Tollip, with a neomycin cassette. |
Phenotypic information | Defective inflammatory responses such as reduced cytokines production. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.;Didierlaurent Arnaud, Brissoni Brian, Velin Dominique, Aebi Natalia, Tardivel Aubry, Käslin Edgar, Sirard Jean Claude, Angelov Georgi, Tschopp Jürg, Burns Kimberly, ;2006;Molecular and cellular biology;26;735-42; 16428431
- Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice.;Liu Yi, Jiang Xiao-Li, Liu Yu, Jiang Ding-Sheng, Zhang Yan, Zhang Rui, Chen Yingjie, Yang Qinglin, Zhang Xiao-Dong, Fan Guo-Chang, Li Hongliang, ;2014;Cardiovascular research;101;87-96; 24285748
- Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia-Reperfusion Injury in Mice.;Yan Zhen-Zhen, Huang Yong-Ping, Wang Xin, Wang Hai-Ping, Ren Fei, Tian Rui-Feng, Cheng Xu, Cai Jie, Zhang Yan, Zhu Xue-Yong, She Zhi-Gang, Zhang Xiao-Jing, Huang Zan, Li Hongliang, ;2019;Hepatology (Baltimore, Md.);70;1750-1769; 31077413
- Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis.;Wan Nian, Liu Xiaoxiong, Zhang Xiao-Jing, Zhao Yichao, Hu Gangying, Wan Fengwei, Zhang Rui, Zhu Xueyong, Xia Hao, Li Hongliang, ;2015;British journal of pharmacology;172;3383-96; 25765712
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