B6.129-Mapk9^tm1Mka/Kctt

Status	Available to order
EMMA ID	EM:01773
International strain name	B6.129-Mapk9^tm1Mka/Kctt
Alternative name	Jnk2-C57Bl6
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Mapk9^tm1Mka
Gene/Transgene symbol	Mapk9

Information from provider

Provider	Ingrid Fossar-Larsen
Provider affiliation	Department of Molecular Cancer Biology, Danish Cancer Society
Genetic information	The Mapk9 (Jnk2) gene is disrupted by insertion of the lacZ cassette at the first exon. This mutation inactivates all known Mapk9 splicing variants.
Phenotypic information	No major defects. Defects in T-cell apoptosis and proliferation. Mice are sensitive to arthritis.
References	c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.;Sabapathy K, Kallunki T, David J P, Graef I, Karin M, Wagner E F, ;2001;The Journal of experimental medicine;193;317-28; 11157052 A central role for JNK in obesity and insulin resistance.;Hirosumi Jiro, Tuncman Gürol, Chang Lufen, Görgün Cem Z, Uysal K Teoman, Maeda Kazuhisa, Karin Michael, Hotamisligil Gökhan S, ;2002;Nature;420;333-6; 12447443 JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.;Sabapathy K, Hu Y, Kallunki T, Schreiber M, David J P, Jochum W, Wagner E F, Karin M, ;1999;Current biology : CB;9;116-25; 10021384 Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis.;Han Zuoning, Chang Lufen, Yamanishi Yuji, Karin Michael, Firestein Gary S, ;2002;Arthritis and rheumatism;46;818-23; 11920420

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (allele matching)

homeostasis/metabolism phenotype / MGI
abnormal physiological response to xenobiotic / MGI
decreased cardiomyocyte apoptosis / MGI
abnormal myocardium layer morphology / MGI
abnormal T cell activation / MGI
decreased T cell proliferation / MGI
decreased T cell apoptosis / MGI
reduced long term potentiation / MGI
abnormal excitatory postsynaptic potential / MGI
decreased paired-pulse facilitation / MGI
decreased post-tetanic potentiation / MGI
abnormal neurotransmitter secretion / MGI

MGI phenotypes (gene matching)

abnormal liver physiology / MGI
thick epidermis / MGI
epidermal hyperplasia / MGI
reduced long term potentiation / MGI
abnormal T cell activation / MGI
abnormal keratinocyte morphology / MGI
abnormal excitatory postsynaptic potential / MGI
decreased paired-pulse facilitation / MGI
decreased post-tetanic potentiation / MGI
decreased cardiomyocyte apoptosis / MGI
decreased T cell proliferation / MGI
decreased susceptibility to injury / MGI
abnormal myocardium layer morphology / MGI
homeostasis/metabolism phenotype / MGI
cardiovascular system phenotype / MGI
abnormal neurotransmitter secretion / MGI
abnormal enzyme/coenzyme activity / MGI
decreased T cell apoptosis / MGI
abnormal T-helper 1 cell differentiation / MGI
abnormal physiological response to xenobiotic / MGI
increased keratohyalin granule number / MGI
decreased sensitivity to induced morbidity/mortality / MGI

Literature references

c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation.;Sabapathy K, Kallunki T, David J P, Graef I, Karin M, Wagner E F, ;2001;The Journal of experimental medicine;193;317-28; 11157052
A central role for JNK in obesity and insulin resistance.;Hirosumi Jiro, Tuncman Gürol, Chang Lufen, Görgün Cem Z, Uysal K Teoman, Maeda Kazuhisa, Karin Michael, Hotamisligil Gökhan S, ;2002;Nature;420;333-6; 12447443
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.;Sabapathy K, Hu Y, Kallunki T, Schreiber M, David J P, Jochum W, Wagner E F, Karin M, ;1999;Current biology : CB;9;116-25; 10021384
Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis.;Han Zuoning, Chang Lufen, Yamanishi Yuji, Karin Michael, Firestein Gary S, ;2002;Arthritis and rheumatism;46;818-23; 11920420

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.129-Mapk9tm1Mka/Kctt