C57BL/6N-Cdkl5tm1.1Ics/Ics
Status | Available to order |
EMMA ID | EM:15616 |
International strain name | C57BL/6N-Cdkl5tm1.1Ics/Ics |
Alternative name | Cdkl5tm1.1Ics (G20) |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Cdkl5tm1.1Ics |
Gene/Transgene symbol | Cdkl5 |
Information from provider
Provider | ICS, Institut Clinique de la Souris |
Provider affiliation | ICS, Institut Clinique de la Souris |
Genetic information | This line was obtained by modification of BD10 in house derived C57BL/6N embryonic stem cells. Exon 4 (ENSMUSE00000346596) was floxed. The flipped NeoR cassette was removed by breeding the male chimeras with flp recombinase deleter females. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:ViableHeterozygous: see DOI: 10.3390/biomedicines10123148 |
Breeding history | Inbred C57BL/6N |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- CDKL5-related epileptic encephalopathy / Orphanet_505652
- Early infantile epileptic encephalopathy / Orphanet_1934
- Atypical Rett syndrome / Orphanet_3095
- West syndrome / Orphanet_3451
Literature references
- Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904
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