- abnormal sternum morphology / MGI
- increased rib number / MGI
- abnormal axial skeleton morphology / MGI
- vertebral transformation / MGI
- cervical vertebral transformation / MGI
- lumbar vertebral transformation / MGI
- thoracic vertebral transformation / MGI
- abnormal odontoid process morphology / MGI
- delayed cellular replicative senescence / MGI
- postnatal lethality, complete penetrance / MGI
- decreased body size / MGI
B6.129S2-Mtf2Gt(U3Betageo)1Ruiz/Cnrm
Status | Available to order |
EMMA ID | EM:01517 |
International strain name | B6.129S2-Mtf2Gt(U3Betageo)1Ruiz/Cnrm |
Alternative name | M016A06 |
Strain type | Gene-trap |
Allele/Transgene symbol | Mtf2Gt(U3Betageo)1Ruiz |
Gene/Transgene symbol | Mtf2 |
Information from provider
Provider | Harald von Melchner |
Provider affiliation | University of Frankfurt Medical School |
Genetic information | Disruption of exon 3 of the Mtf2 gene by the U3bgeo retroviral gene trap vector. |
Phenotypic information | Skeletal abnormalities (abnormal head shape, bent nasal bone, C1 fused to C2), significant growth retardation, perinatal lethality with incomplete penetrance (phenotype reminiscent of bromodomain containing protein 4, Brd4, mutants), inflammatory infiltrates in liver, degenerative changes in skeletal muscle (loss of stria associated with regenerative proliferation). |
Breeding history | Backcrossed over 6 generations. |
References |
|
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal sternum morphology / MGI
- kyphosis / MGI
- increased rib number / MGI
- kinked tail / MGI
- decreased body weight / MGI
- decreased body size / MGI
- postnatal growth retardation / MGI
- hydroencephaly / MGI
- decreased litter size / MGI
- abnormal axial skeleton morphology / MGI
- vertebral transformation / MGI
- cervical vertebral transformation / MGI
- lumbar vertebral transformation / MGI
- thoracic vertebral transformation / MGI
- abnormal odontoid process morphology / MGI
- abnormal incisor morphology / MGI
- embryo phenotype / MGI
- delayed cellular replicative senescence / MGI
- postnatal lethality, complete penetrance / MGI
- misaligned incisors / MGI
Literature references
- A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
- Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.;Houzelstein Denis, Bullock Simon L, Lynch Denise E, Grigorieva Elena F, Wilson Valerie A, Beddington Rosa S P, ;2002;Molecular and cellular biology;22;3794-802; 11997514
- Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.;Li Xiangzhi, Isono Kyo-Ichi, Yamada Daisuke, Endo Takaho A, Endoh Mitsuhiro, Shinga Jun, Mizutani-Koseki Yoko, Otte Arie P, Casanova Miguel, Kitamura Hiroshi, Kamijo Takehiko, Sharif Jafar, Ohara Osamu, Toyada Tetsuro, Bernstein Bradley E, Brockdorff Neil, Koseki Haruhiko, ;2011;Molecular and cellular biology;31;351-64; 21059868
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).