B6.Cg-Parp3tm1.2Ics/Orl
| Status | Available to order |
| EMMA ID | EM:14722 |
| International strain name | B6.Cg-Parp3tm1.2Ics/Orl |
| Alternative name | Parp3 knockout mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Parp3tm1.2Ics, |
| Gene/Transgene symbol | Parp3 |
Information from provider
| Provider | Françoise Dantzer |
| Provider affiliation | Biotechnology and Cell Signaling, UMR7242, CNRS |
| Genetic information | Disruption of the Parp3 gene. The Parp3+/- mice were generated by breeding mice carrying a conditional Parp3 (flox) allele with mice expressing a ubiquitously active CMV-cre transgene. The detailed description of the generation of the Parp3 knockout mice is provided in Boehler et al. PNAS (2011) 108(7):2783-8. doi: 10.1073/pnas.1016574108. |
| Phenotypic information | Homozygous:No overt abnormal phenotype. Increased sensitivity to X irradiation in the double Parp1-/-; Parp3-/- knockout mice.Heterozygous:No overt abnormal phenotype. |
| Breeding history | Over 10 backcross to the C57BL/6 background were performed. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J |
Literature references
- Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.;Boehler Christian, Gauthier Laurent R, Mortusewicz Oliver, Biard Denis S, Saliou Jean-Michel, Bresson Anne, Sanglier-Cianferani Sarah, Smith Susan, Schreiber Valérie, Boussin François, Dantzer Françoise, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;2783-8; 21270334