- decreased hematocrit / MGI
- abnormal liver physiology / MGI
- abnormal T cell differentiation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal immunoglobulin level / MGI
- increased IgM level / MGI
- abnormal cytokine secretion / MGI
- thyroid inflammation / MGI
- increased autoantibody level / MGI
- insulitis / MGI
- increased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to parasitic infection / MGI
- immune system phenotype / MGI
- periinsulitis / MGI
- abnormal T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
B10.Cg-H2p Tg(CD68-H2-Ab1q)#Rhd/RhdKctt
Status | Available to order |
EMMA ID | EM:01349 |
International strain name | B10.Cg-H2p Tg(CD68-H2-Ab1q)#Rhd/RhdKctt |
Alternative name | MBQ |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(CD68-H2-Ab1q)#Rhd, H2p |
Gene/Transgene symbol | Tg(CD68-H2-Ab1q)#Rhd, H2 |
Information from provider
Provider | Rikard Holmdahl |
Provider affiliation | Lund University, CMB, Section for medical inflammation reseach |
Genetic information | The MBQ (macrophage A Beta Q) strain expresses the H2 I-A q beta chain in macrophages, only. The expression is strain-independent. |
Phenotypic information | None. |
Breeding history | Backcrossed to B10.P for more than 20 generations. |
References |
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Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species.;Pizzolla Angela, Gelderman Kyra A, Hultqvist Malin, Vestberg Mikael, Gustafsson Kenth, Mattsson Ragnar, Holmdahl Rikard, ;2011;European journal of immunology;41;403-12; 21268010
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