IMPC phenotypes (gene matching)
- hypoalgesia / IMPC
B6J.B6N(Cg)-Htr3atm1c(EUCOMM)Wtsi/Cnbc
| Status | Available to order |
| EMMA ID | EM:12234 |
| International strain name | B6J.B6N(Cg)-Htr3atm1c(EUCOMM)Wtsi/Cnbc |
| Alternative name | Htr3a tm1c(EUCOMM)Wtsi ES cell line: JM8A3.N1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Htr3atm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Htr3a |
Information from provider
| Provider | Miguel Soares |
| Provider affiliation | Biomedicine, Faculty of Medicine of the University of Porto |
| Genetic information | Gene targeted: Htr3a (5-hydroxytryptamine (serotonin) receptor 3A; MGI:96282). FLPed knock-out first allele (tm1c) with conditional potential. |
| Phenotypic information | Homozygous:No abnormal phenotype detectedHeterozygous:No abnormal phenotype detected |
| Breeding history | 10+ generations. First backcrosses (not with parents but with unrelated C57BL/6J animals), then intercrosses (avoided consanguinity). |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased bone marrow cell number / MGI
- hydronephrosis / MGI
- abnormal urinary bladder morphology / MGI
- distended urinary bladder / MGI
- abnormal urinary bladder urothelium morphology / MGI
- abnormal urination pattern / MGI
- kidney inflammation / MGI
- premature death / MGI
- increased urine protein level / MGI
- urinary incontinence / MGI
- prostate gland inflammation / MGI
- decreased lymphocyte cell number / MGI
- cachexia / MGI
- neurogenic bladder / MGI
- increased blood urea nitrogen level / MGI
- increased chemical nociceptive threshold / MGI
- urinary bladder obstruction / MGI
- abnormal urinary bladder physiology / MGI
- pyelonephritis / MGI
- tubulointerstitial nephritis / MGI
- abnormal urinary bladder detrusor smooth muscle morphology / MGI
- abnormal male prostatic urethra morphology / MGI
- abnormal urinary bladder neck morphology / MGI
- increased urinary bladder weight / MGI
- urethra obstruction / MGI
- seminal vesiculitis / MGI