IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
B6NTac(Cg)-Raph1tm1.1Makr/H
| Status | Available to order |
| EMMA ID | EM:11784 |
| International strain name | B6NTac(Cg)-Raph1tm1.1Makr/H |
| Alternative name | Raph1tm1.1Makr |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Raph1tm1.1Makr |
| Gene/Transgene symbol | Raph1 |
Information from provider
| Provider | Matthias Krause |
| Provider affiliation | Randall Centre for Cell & Molecular Biophysics, King |
| Genetic information | An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. |
| Phenotypic information | Homozygous:No phenotype in this conditional strain but phenotypes when crossed to cre-deleter or nestin-cre driver strains; see http://www.informatics.jax.org/image/phenoSummary/allele/MGI:5575553 and https://www.ncbi.nlm.nih.gov/pubmed/28710397?dopt=Abstract.Heterozygous:No phenotype in this conditional strain. |
| Breeding history | Maintained on same genetic background |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal rectum morphology / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- increased inflammatory response / MGI
- increased carcinoma incidence / MGI
- increased susceptibility to bacterial infection / MGI
- no phenotypic analysis / MGI
- intestinal edema / MGI
- large intestinal inflammation / MGI
- abnormal cytokine level / MGI
- increased myeloid cell number / MGI
Literature references
- Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.;Law Ah-Lai, Vehlow Anne, Kotini Maria, Dodgson Lauren, Soong Daniel, Theveneau Eric, Bodo Cristian, Taylor Eleanor, Navarro Christel, Perera Upamali, Michael Magdalene, Dunn Graham A, Bennett Daimark, Mayor Roberto, Krause Matthias, ;2013;The Journal of cell biology;203;673-89; 24247431
- Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice.;Bodo Cristian, Fernandes Cathy, Krause Matthias, ;2017;Scientific reports;7;5365; 28710397