IMPC phenotypes (gene matching)
DUSP1flox
| Status | Available to order |
| EMMA ID | EM:11372 |
| International strain name | DUSP1flox |
| Alternative name | DUSP1flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Dusp1tm1 |
| Gene/Transgene symbol | Dusp1 |
Information from provider
| Provider | Rosario Perona |
| Provider affiliation | Experimental models for human diseases, Instituto de Investigaciones Biomedicas CSIC/UAM |
| Genetic information | A single loxP site and a FRT-neo-FRT-loxP resistance cassette were simultaneously inserted into the Dusp1 genomic locus so as to target exon 2 for Cre-mediated excision. |
| Phenotypic information | Homozygous:We found no phenotype since it is a carrier strain to be crossed with a cre recombinase expressing strain.Heterozygous:We found no phenotype since it is a carrier strain to be crossed with a cre recombinase expressing strain. |
| Breeding history | Embryos made in CD1 background generated chimeras that were then crossed with C57BL/6J. 5 different crosses were performed to obtain homozygous DUSP1flox on C57BL/6J mouse. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6.Cg, homozygous C57BL/6.Cg |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased granulocyte number / MGI
- small liver / MGI
- abnormal myogenesis / MGI
- abnormal muscle development / MGI
- abnormal muscle regeneration / MGI
- abnormal superior cervical ganglion morphology / MGI
- thick pulmonary interalveolar septum / MGI
- decreased body weight / MGI
- weight loss / MGI
- decreased anxiety-related response / MGI
- abnormal eating behavior / MGI
- abnormal circulating alanine transaminase level / MGI
- hypotension / MGI
- lung inflammation / MGI
- decreased susceptibility to hepatic steatosis / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal innate immunity / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating free fatty acid level / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- increased neuron apoptosis / MGI
- decreased susceptibility to age related obesity / MGI
- abnormal locomotor activation / MGI
- abnormal depression-related behavior / MGI
- abnormal gluconeogenesis / MGI
- decreased liver weight / MGI
- increased susceptibility to induced arthritis / MGI
- pulmonary edema / MGI
- abnormal nitric oxide homeostasis / MGI
- increased energy expenditure / MGI
- decreased circulating cholesterol level / MGI
- homeostasis/metabolism phenotype / MGI
- immune system phenotype / MGI
- decreased body temperature / MGI
- increased blood urea nitrogen level / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased systemic arterial systolic blood pressure / MGI
- abnormal dendrite morphology / MGI
- increased circulating tumor necrosis factor level / MGI
- increased tumor necrosis factor secretion / MGI
- increased circulating interferon-gamma level / MGI
- increased circulating interleukin-10 level / MGI
- increased circulating interleukin-6 level / MGI
- increased interleukin-1 beta secretion / MGI
- increased interleukin-6 secretion / MGI
- abnormal chemokine level / MGI
- abnormal chemokine secretion / MGI
- increased susceptibility to endotoxin shock / MGI
- abnormal interleukin level / MGI
- increased mast cell degranulation / MGI
- decreased fat cell size / MGI
- decreased abdominal fat pad weight / MGI
- decreased epididymal fat pad weight / MGI
- decreased skeletal muscle fiber size / MGI
- decreased skeletal muscle fiber diameter / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased prostaglandin level / MGI
- decreased total body fat amount / MGI
- increased respiratory quotient / MGI
- abnormal cellular respiration / MGI