- decreased body weight / MGI
- abnormal placenta labyrinth morphology / MGI
- postnatal growth retardation / MGI
- fetal growth retardation / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased fetal weight / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal syncytiotrophoblast morphology / MGI
129(Cg)-Synbtm1.2Ics/Orl
Status | Available to order |
EMMA ID | EM:11298 |
International strain name | 129(Cg)-Synbtm1.2Ics/Orl |
Alternative name | 129/sv Syncytin-B KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Synbtm1.2Ics, |
Gene/Transgene symbol | Synb |
Information from provider
Provider | Thierry Heidmann |
Provider affiliation | Insitut Gustave Roussy, UMR9196 CNRS |
Genetic information | Mice containing an excised copy of the syncytin-B open reading frame. |
Phenotypic information | Homozygous:Homozygous null embryos display an impaired placentation, with late onset growth retardation and reduced neonate numbers.Heterozygous:no alteration |
Breeding history | The original founder (B6.129/Sv) was backcrossed 10 times to 129/Sv. Then, four homozygous mutant siblings, obtained from two couples, were bred and the mutant strain was subsequently maintained in a homozygous state for more than 7 generations. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous 129 |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.;Dupressoir Anne, Vernochet Cécile, Harper Francis, Guégan Justine, Dessen Philippe, Pierron Gérard, Heidmann Thierry, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;E1164-73; 22032925
- Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice.;Redelsperger François, Raddi Najat, Bacquin Agathe, Vernochet Cécile, Mariot Virginie, Gache Vincent, Blanchard-Gutton Nicolas, Charrin Stéphanie, Tiret Laurent, Dumonceaux Julie, Dupressoir Anne, Heidmann Thierry, ;2016;PLoS genetics;12;e1006289; 27589388
- Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice.;Coudert Amélie E, Redelsperger François, Chabbi-Achengli Yasmine, Vernochet Cécile, Marty Caroline, Decrouy Xavier, Heidmann Thierry, de Vernejoul Marie-Christine, Dupressoir Anne, ;2019;Bone reports;11;100214; 31360740
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