B6.Cg-Tnfrsf1atm3Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:11070 |
| International strain name | B6.Cg-Tnfrsf1atm3Gkl/Flmg |
| Alternative name | B6.Cg-Tnfrsf1a |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tnfrsf1atm3Gkl |
| Gene/Transgene symbol | Tnfrsf1a |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Fleming |
| Genetic information | A targeting vector has been generated to induce homologous recombination in ES cells, with exons 2–5 flanked by loxP sites, which upon recombination will result in a frame shift mutation. |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
Literature references
- FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.;Victoratos Panayiotis, Lagnel Jacques, Tzima Sotiria, Alimzhanov Marat B, Rajewsky Klaus, Pasparakis Manolis, Kollias George, ;2006;Immunity;24;65-77; 16413924