B6.129P2(Cg)-Tnfrsf1atm3.3Gkl/Flmg
Status | Available to order |
EMMA ID | EM:11019 |
International strain name | B6.129P2(Cg)-Tnfrsf1atm3.3Gkl/Flmg |
Alternative name | B6.129P2(Cg)-Tnfrsf1a |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tnfrsf1atm3.3Gkl, |
Gene/Transgene symbol | Tnfrsf1a |
Information from provider
Provider | George Kollias |
Provider affiliation | BSRC Fleming |
Genetic information | An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. A second loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 2 through 5 floxed. Cre-mediated recombination, specific to the myeloid lineage, removed exons 2 through 5. |
Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | heterozygous C57BL/6 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
Literature references
- Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.;Van Hauwermeiren Filip, Armaka Marietta, Karagianni Niki, Kranidioti Ksanthi, Vandenbroucke Roosmarijn E, Loges Sonja, Van Roy Maarten, Staelens Jan, Puimège Leen, Palagani Ajay, Berghe Wim Vanden, Victoratos Panayiotis, Carmeliet Peter, Libert Claude, Kollias George, ;2013;The Journal of clinical investigation;123;2590-603; 23676465
- Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice.;Wroblewski Raluca, Armaka Marietta, Kondylis Vangelis, Pasparakis Manolis, Walczak Henning, Mittrücker Hans-Willi, Schramm Christoph, Lohse Ansgar W, Kollias George, Ehlken Hanno, ;2016;Hepatology (Baltimore, Md.);64;508-21; 26991125
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