B6.Cg-Tg(KRT14-Lgals7)34Ijmfp/Cnbc
| Status | Available to order |
| EMMA ID | EM:10966 |
| International strain name | B6.Cg-Tg(KRT14-Lgals7)34Ijmfp/Cnbc |
| Alternative name | Tg-K14galectin7 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT14-Lgals7)34Ijmfp |
| Gene/Transgene symbol | Tg(KRT14-Lgals7)34Ijmfp |
Information from provider
| Provider | francoise POIRIER |
| Provider affiliation | UMR 7592 CNRS-Université Paris Diderot, Institut Jacques Monod |
| Genetic information | As described in Gendronneau 2015, C57BL/6;DBA/2 oocytes were microinjected with a construct containing the rat galectin-7 cDNA placed downstream of the keratin14 (K14) promoter (Saitou et al., 1995). |
| Phenotypic information | Homozygous:Normal lifespan, mild epidermis defects.Heterozygous:Normal lifespan, mild epidermis defects. |
| Breeding history | Founder animals carrying the transgene were mated with C57BL/6 individuals and two independent K14-galectin-7 transgenic lines. Tg34 was established after eight successive backcrosses on the C57BL/6 background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J |
Literature references
- Overexpression of galectin-7 in mouse epidermis leads to loss of cell junctions and defective skin repair.;Gendronneau Gaëlle, Sanii Sadaf, Dang Tien, Deshayes Frédérique, Delacour Delphine, Pichard Evelyne, Advedissian Tamara, Sidhu Sukhvinder S, Viguier Mireille, Magnaldo Thierry, Poirier Francoise, ;2015;PloS one;10;e0119031; 25741714