IMPC phenotypes (gene matching)
B6.Cg-Rock1tm1.1Skmp/SkmpH
| Status | Available to order |
| EMMA ID | EM:10372 |
| International strain name | B6.Cg-Rock1tm1.1Skmp/SkmpH |
| Alternative name | Rock1 (C57Bl6J) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Rock1tm1.1Skmp |
| Gene/Transgene symbol | Rock1 |
Information from provider
| Provider | Afshan McCarthy |
| Provider affiliation | Cancer Biology, Institute of Cancer Research |
| Genetic information | Conditionally targeted allele of Rock1. |
| Phenotypic information | Homozygous:Floxed homozygous mice are viable and have a normal lifespan.Heterozygous:Floxed heterozygous mice are viable and have a normal lifespan. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6J |
| Breeding at archiving centre | No additional breeding was done at the repository |
Disease and phenotype information
Literature references
- Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.;Kümper Sandra, Mardakheh Faraz K, McCarthy Afshan, Yeo Maggie, Stamp Gordon W, Paul Angela, Worboys Jonathan, Sadok Amine, Jørgensen Claus, Guichard Sabrina, Marshall Christopher J, ;2016;eLife;5;e12994; 26765561