STOCK Tnfrsf1atm1Blt Tg(CD2/HBB-TNF*)5453Gkl/Flmg


Available to order

International strain nameSTOCK Tnfrsf1atm1Blt Tg(CD2/HBB-TNF*)5453Gkl/Flmg
Alternative nameTg5453 [CBA;B6-Tnfrsf1a Tg(CD2/HBB-TNF*)5453Gkl /Flmg]
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTnfrsf1atm1Blt,
Gene/Transgene symbolTnfrsf1a

Information from provider

ProviderGeorge Kollias
Provider affiliationImmunology, BSRC Al. Fleming
Genetic informationA mutant uncleavable form of the 26 kD protein was engineered by the deletion of the codons for the first to the twelfth amino acids of the wild type gene. This produces a membrane-associated protein that is bioactive. Under the control of the T cell specific human CD2 gene locus control region (LCR).
Phenotypic informationHomozygous:

Humanized transgenic mouse with a T-cell-target transmembrane human TNF deregulated expression, which results in the spontaneous development of arthritis pathology closely resembling that of human rheumatoid arthritis.
  • Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.;Georgopoulos S, Plows D, Kollias G, ;1996;Journal of inflammation;46;86-97; 8734789
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivingheterozygous 0, wild-type (CBA x C57BL/6)F1
Stage of embryosMorula

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
MGI phenotypes (allele matching)
  • abnormal response/metabolism to endogenous compounds / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal sleep pattern / MGI
  • impaired central nervous system regeneration / MGI
  • increased sensitivity to induced cell death / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • impaired humoral immune response / MGI
  • decreased susceptibility to bacterial infection / MGI
  • decreased circulating alanine transaminase level / MGI
  • abnormal Peyer's patch morphology / MGI
  • abnormal immune system physiology / MGI
  • abnormal lymph node B cell domain morphology / MGI
  • abnormal Peyer's patch follicle morphology / MGI
  • increased susceptibility to bacterial infection / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased susceptibility to type I hypersensitivity reaction / MGI
  • decreased Peyer's patch number / MGI
  • absent follicular dendritic cells / MGI
  • decreased IgG1 level / MGI
  • decreased interleukin-6 secretion / MGI

Literature references

  • Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.;Georgopoulos S, Plows D, Kollias G, ;1996;Journal of inflammation;46;86-97; 8734789

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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