STOCK Rag2tm1Fwa Ifnar1tm Tg(TcrLCMV)327Sdz/Orl


Available to order

International strain nameSTOCK Rag2tm1Fwa Ifnar1tm Tg(TcrLCMV)327Sdz/Orl
Alternative nameP14TCR-TG/Rag2-/-/InfaR-/- mice
Strain typeTransgenic Strains
Allele/Transgene symbolTg(TcrLCMV)327Sdz,
Gene/Transgene symbolTg(TcrLCMV)327Sdz

Information from provider

ProviderBenedita Rocha
Provider affiliationINSERM U 1020, INSERM
Additional ownerI am exclusive owner of this crossing, but not of the individual strains used for the crossing that are generaly available without restrictions.
Genetic informationThis strain was generated by crossing the P14 transgenic mice, which bear a TCR transgene specific for the GP33-peptide of the Leukocyte Choriomeningitis Virus (LCMV), with two deficient mouse strains. The first was deficient in the recombinase Rag2 and the second in the receptor for the interferon alpha (Ifnar1, prev. InfaR). The resulting strain allows the study of the influence of interferon alpha (which is produced in very high amounts during LCMV infection) in the response of CD8 T cells to LCMV. We would cryopreserve this crossing since the fixation in the same mouse strain of 2 targeted mutations and one transgene was very difficult and we believe it will be of major interest to the immunology community.
Phenotypic informationMice will have a single population of lymphocytes, those expressing the TCR transgene.
Breeding historyCurrently bred homozygous for the Rag2 mutation and the TCR transgene, heterozygous for the Ifnar1 (InfarR) mutation.
ReferencesNone available
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J, wild-type C57BL/6J
Breeding at archiving centreMales knock-out for Rag2 and Ifnar1 (InfaR), homozygous transgenic for Tg(TcrLCMV)327Sdz (P14TCR). Females heterozygous or wild-type for each mutation.
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased granulocyte number / MGI
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • decreased body size / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • thymus hypoplasia / MGI
  • arrested T cell differentiation / MGI
  • increased susceptibility to infection / MGI
  • abnormal effector T cell morphology / MGI
  • increased natural killer cell mediated cytotoxicity / MGI
  • decreased double-positive T cell number / MGI
  • increased macrophage cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • lymph node hypoplasia / MGI
  • absent mature B cells / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • decreased thymocyte number / MGI
  • lung inflammation / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • colitis / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal response to transplant / MGI
  • abnormal interferon secretion / MGI
  • abnormal chemokine secretion / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal intestinal mucosa morphology / MGI
  • abnormal B cell morphology / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased double-negative T cell number / MGI
  • increased double-negative T cell number / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal stomach mucosa morphology / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal B cell number / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • decreased immature B cell number / MGI
  • abnormal gamma-delta T cell differentiation / MGI
  • autoimmune response / MGI

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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