STOCK Nfkbiatm1Kbp Tg(KRT14-cre)1Cgn/Ieg
Status | Available to order |
EMMA ID | EM:06271 |
International strain name | STOCK Nfkbiatm1Kbp Tg(KRT14-cre)1Cgn/Ieg |
Alternative name | K14cre Ikba |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Nfkbiatm1Kbp, |
Gene/Transgene symbol | Nfkbia |
Information from provider
Provider | Rudolf Rupec |
Provider affiliation | Derma AG |
Genetic information | Inducible skin specific deletion of Nfkbia (promoter region containing essential regulatory NF-kappaB binding sites, the core promoter, and the first two exons) with cre-loxP system. Cre-expression linked to keratin 14. |
Phenotypic information | Persistent skin inflammation; psoriasis like. |
References |
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Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6N, wild-type C57BL/6N |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Nasopharyngeal carcinoma / Orphanet_150
- Hypohidrotic ectodermal dysplasia with immunodeficiency / Orphanet_98813
Literature references
- Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin.;Rebholz Bernd, Haase Ingo, Eckelt Birgit, Paxian Stephan, Flaig Michael J, Ghoreschi Kamran, Nedospasov Sergei A, Mailhammer Reinhard, Debey-Pascher Svenja, Schultze Joachim L, Weindl Günther, Förster Irmgard, Huss Ralf, Stratis Athanasios, Ruzicka Thomas, Röcken Martin, Pfeffer Klaus, Schmid Roland M, Rupec Rudolf A, ;2007;Immunity;27;296-307; 17692539
- Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha.;Rupec Rudolf A, Jundt Franziska, Rebholz Bernd, Eckelt Birgit, Weindl Günther, Herzinger Thomas, Flaig Michael J, Moosmann Sabine, Plewig Gerd, Dörken Bernd, Förster Irmgard, Huss Ralf, Pfeffer Klaus, ;2005;Immunity;22;479-91; 15845452
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