B6;129P2-Nkx6-2tm1Ercs/Kctt
Status | Available to order |
EMMA ID | EM:06021 |
International strain name | B6;129P2-Nkx6-2tm1Ercs/Kctt |
Alternative name | Nkx6.2tm1Ercs / Nkx6.2LacZ |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Nkx6-2tm1Ercs, |
Gene/Transgene symbol | Nkx6-2 |
Information from provider
Provider | Elisabet Andersson |
Provider affiliation | Dept. Comparative Medicine, KCTT, Karolinska Institutet |
Genetic information | The entire coding region was replaced with a cassette containing tau-lacZ and neomycin. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. |
Phenotypic information | Mice homozygous for the mutant alleles were born at Mendelian frequency and survived through adulthood. No abnormal phenotype was observed. Nervous system abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve; abnormal vagus ganglion morphology: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve. Cellular abnormal axon outgrowth: axonal tracts are thinner than in wild-type mice, especially for the tenth cranial nerve. |
Breeding history | Mixed, not congenic. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Animals used for archiving | wild-type C57BL/6 |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- NKX6-2-related autosomal recessive hypomyelinating leukodystrophy / Orphanet_527497
Literature references
- Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification.;Vallstedt A, Muhr J, Pattyn A, Pierani A, Mendelsohn M, Sander M, Jessell T M, Ericson J, ;2001;Neuron;31;743-55; 11567614
- Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.;Pattyn Alexandre, Vallstedt Anna, Dias Jose M, Sander Maike, Ericson Johan, ;2003;Development (Cambridge, England);130;4149-59; 12874134
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).