- behavior/neurological phenotype / MGI
B6;D2-Tg(Eno2-MFN2)L916Ugfm/Orl
Status | Available to order |
EMMA ID | EM:04782 |
International strain name | B6;D2-Tg(Eno2-MFN2)L916Ugfm/Orl |
Alternative name | MitoCharc0 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Eno2-MFN2)L916Ugfm, |
Gene/Transgene symbol | Tg(Eno2-MFN2)L916Ugfm |
Information from provider
Provider | Romain Cartoni |
Provider affiliation | F.M. Kirby Neurobiology Center , Children |
Genetic information | The MitoCharc0 transgene was designed with the human mitofusin 2 (MNF2) gene driven by a neuron specific enolase promoter. The transgene was microinjected into fertilized C57BL/6 x DBA/2 F1 oocytes, and founder mice were bred to C57BL/6J mice to establish a colony. |
Phenotypic information | MitoCharc0 transgenic mice display no obvious phenotypes. This strain was generated as a control of the two mutant strains MitoCharc1 and 2. |
Breeding history | Founders with the mixed background C57BL/6 x B6D2F1 were first bred with pure C57BL/6. Transgenic hemizygotes were bred with non-Tg mice from these breedings. |
References |
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Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous , wild-type C57BL/6J |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.;Cartoni Romain, Arnaud Estelle, Médard Jean-Jacques, Poirot Olivier, Courvoisier Delphine S, Chrast Roman, Martinou Jean-Claude, ;2010;Brain : a journal of neurology;133;1460-9; 20418531
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