Available to order

International strain nameB6;C3-Faslgld/Orl
Alternative nameC57BL/6 - gld
Strain typeSpontaneous
Allele/Transgene symbolFaslgld,
Gene/Transgene symbolFasl

Information from provider

ProviderS Nagata
Provider affiliationOsaka Bioscience Institute
Phenotypic informationMutant strain for Fasl-gld (Fas ligand, generalized lymphoproliferative disease) allele; prev. nomenclature: Tnfsf6-gld (tumor necrosis factor ligand superfamily member 6, gld). The gld allele is generated by a point mutation in the C-terminal region of the Fasl protein. The homozygous gld mice develop lymphadenopathy and have autoimmune diseases.
  • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.;Takahashi T, Tanaka M, Brannan C I, Jenkins N A, Copeland N G, Suda T, Nagata S, ;1994;Cell;76;969-76; 7511063

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • increased leukocyte cell number / MGI
  • increased neutrophil cell number / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • anemia / MGI
  • skin edema / MGI
  • interstitial pneumonia / MGI
  • neoplasm / MGI
  • premature death / MGI
  • abnormal T cell differentiation / MGI
  • abnormal lymph node morphology / MGI
  • increased immunoglobulin level / MGI
  • increased IgG level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • increased autoantibody level / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased lymphocyte cell number / MGI
  • increased T cell number / MGI
  • decreased B cell number / MGI
  • decreased cytotoxic T cell cytolysis / MGI
  • renal/urinary system phenotype / MGI
  • cardiovascular system phenotype / MGI
  • increased IgG1 level / MGI
  • increased IgG2a level / MGI
  • increased IgG2b level / MGI
  • mortality/aging / MGI
  • decreased granulocyte number / MGI
  • abnormal hepatocyte morphology / MGI
  • demyelination / MGI
  • abnormal osteoclast physiology / MGI
  • focal hepatic necrosis / MGI
  • brain inflammation / MGI
  • eye inflammation / MGI
  • liver inflammation / MGI
  • increased susceptibility to bacterial infection / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal sperm number / MGI
  • decreased circulating alanine transaminase level / MGI
  • abnormal sperm physiology / MGI
  • abnormal eye electrophysiology / MGI
  • CNS inflammation / MGI
  • decreased hepatocyte apoptosis / MGI
  • abnormal NK cell physiology / MGI
  • abnormal T cell physiology / MGI
  • decreased neuron apoptosis / MGI
  • abnormal T cell proliferation / MGI
  • abnormal T cell morphology / MGI
  • abnormal interleukin level / MGI
  • impaired macrophage phagocytosis / MGI
  • increased spleen weight / MGI
  • homeostasis/metabolism phenotype / MGI
  • increased apoptosis / MGI
  • dermatitis / MGI
  • increased IgE level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • decreased susceptibility to injury / MGI
  • immune system phenotype / MGI
  • increased circulating tumor necrosis factor level / MGI
  • increased histiocytic sarcoma incidence / MGI
  • reproductive system phenotype / MGI

Literature references

  • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.;Takahashi T, Tanaka M, Brannan C I, Jenkins N A, Copeland N G, Suda T, Nagata S, ;1994;Cell;76;969-76; 7511063

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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