Available to order

International strain nameB6;129S5-Rras2Gt(OST47398)Lex/Ieg
Alternative nameLEXKO-648, RASTC21_1
Strain typeGene-trap
Allele/Transgene symbolRras2Gt(OST47398)Lex,
Gene/Transgene symbolRras2

Information from provider

Provider Lexicon Genetics, Inc.
Provider affiliationLexicon Pharmaceuticals
Phenotypic informationOphthalmic observations found reduced mean artery-to-vein ratio in the homozygous mutant mice as compared to wild-type littermates. In microscopic examination, homozygotes showed signs of retinal degeneration characterized by a reduction in thickness of external nuclear and photoreceptor layers as well as vacuolization of photoreceptor and external plexiorm layers. The male homozygotes also had a higher mean total tissue mass and mean total body fat as compared to the gender-matched wild-type littermates. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased body size / MGI
  • retinal degeneration / MGI
  • abnormal retinal vasculature morphology / MGI
  • abnormal retinal photoreceptor layer morphology / MGI
  • abnormal retinal outer plexiform layer morphology / MGI
  • thin retinal outer nuclear layer / MGI
  • increased total body fat amount / MGI

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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