Available to order

International strain nameC57BL/6-Hnrnpllthdr/ApbH
Alternative nameThunder
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolHnrnpllthdr,
Gene/Transgene symbolHnrnpll

Information from provider

ProviderChris Goodnow
Provider affiliationThe Australian National University
Genetic informationThis strain was identified during systematic screening of the mouse genome for autoimmune regulators. The point mutation causing the phenotype has been identified. This mutation opens up the connection between cell surface receptor expression and T cell regulation.
Phenotypic informationThis strain has entirely normal thymic development and single positive cells, but a marked reduction in the number of peripheral T cells especially naive CD4 and CD8 cells, and poor survival of thunder T cells upon adoptive transfer. The T cells are hyperactivated. There is a 50-fold increase in CD45R (Ptprc) A, B or C staining on all thymocytes and peripheral T cells, as well as macrophages and dendritic cells, low T cell numbers which are hyperactivated.
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal T cell differentiation / MGI
  • abnormal memory T cell physiology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • abnormal memory T cell morphology / MGI

Information on how we integrate external resources can be found here



Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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