STOCK Fasltm1.1Cgm/Ieg


Available to order

International strain nameSTOCK Fasltm1.1Cgm/Ieg
Alternative nameFasL delta intra k.o./k.i.
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolFasltm1.1Cgm,
Gene/Transgene symbolFasl

Information from provider

ProviderMartin Zoernig
Provider affiliationChemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt
Genetic informationThe wild-type Fas ligand (Fasl) allele was replaced with a deletion mutant which lacks the intracellular domain (i.e. aa 2-73). The targeting construct contained a tk-neo fusion cassette flanked by loxP sites for positive selection. This tk-neo cassette has been removed after breeding with CMV-cre recombinase deleter mice.
Phenotypic informationHomozygous mutants develop a lymphoaccumulation of T-cells in the periphery, similar to Fas ligand-deficient gld/gld mice (of a strain with a Fas ligand spontaneous mutant allele). In addition, mice probably develop autoimmune defects, again similar to gld/gld mice. Therefore, homozygous mice die within 4-6 months of age in the C57BL/6 background.
Breeding historyBackcrossed to C57BL/6 for 4 generations.
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased IgM level / MGI
  • increased B cell proliferation / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI
  • increased plasma cell number / MGI
  • increased germinal center B cell number / MGI

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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