- abnormal embryo development / MGI
- abnormal ectoderm development / MGI
- abnormal mesoderm development / MGI
- decreased embryo size / MGI
- embryonic growth arrest / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal gastrulation movements / MGI
- disorganized extraembryonic tissue / MGI
- abnormal trophoblast layer morphology / MGI
- abnormal extraembryonic mesoderm development / MGI
- embryonic lethality, complete penetrance / MGI
- abnormal amniotic cavity morphology / MGI
- absent ectoplacental cavity / MGI
- small proamniotic cavity / MGI
- absent extraembryonic coelom / MGI
- small amniotic cavity / MGI
- embryonic-extraembryonic boundary constriction / MGI
B6.129P2-Tln1tm1Crit/CritH
Status | Available to order |
EMMA ID | EM:00185 |
International strain name | B6.129P2-Tln1tm1Crit/CritH |
Alternative name | Tln1((hyg/+)/C57) |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tln1tm1Crit, |
Gene/Transgene symbol | Tln1 |
Information from provider
Provider | Martin FRAY |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | The endogenous locus was disrupted by insertion of a hygromycin selection cassette. Codons 37 through 66 were deleted by the insertion. |
Phenotypic information | Talin binds directly to selected integrin beta-subunit cytodomains and to F-actin. This interaction is disrupted in mice homozygous for this knock-out allele. |
Breeding history | The original founder stock has been repeatedly (more than 8 generations) backcrossed to C57BL/6J. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Disruption of the talin gene arrests mouse development at the gastrulation stage.;Monkley S J, Zhou X H, Kinston S J, Giblett S M, Hemmings L, Priddle H, Brown J E, Pritchard C A, Critchley D R, Fässler R, ;2000;Developmental dynamics : an official publication of the American Association of Anatomists;219;560-74; 11084655
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