B6.129P2-Tln1tm1Crit/CritH

Status

Available to order

EMMA IDEM:00185
International strain nameB6.129P2-Tln1tm1Crit/CritH
Alternative nameTln1((hyg/+)/C57)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTln1tm1Crit,
Gene/Transgene symbolTln1

Information from provider

ProviderMartin FRAY
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationThe endogenous locus was disrupted by insertion of a hygromycin selection cassette. Codons 37 through 66 were deleted by the insertion.
Phenotypic informationTalin binds directly to selected integrin beta-subunit cytodomains and to F-actin. This interaction is disrupted in mice homozygous for this knock-out allele.
Breeding historyThe original founder stock has been repeatedly (more than 8 generations) backcrossed to C57BL/6J.
References
  • Disruption of the talin gene arrests mouse development at the gastrulation stage.;Monkley S J, Zhou X H, Kinston S J, Giblett S M, Hemmings L, Priddle H, Brown J E, Pritchard C A, Critchley D R, Fässler R, ;2000;Developmental dynamics : an official publication of the American Association of Anatomists;219;560-74; 11084655

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal embryo development / MGI
  • abnormal ectoderm development / MGI
  • abnormal mesoderm development / MGI
  • decreased embryo size / MGI
  • embryonic growth arrest / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal gastrulation movements / MGI
  • disorganized extraembryonic tissue / MGI
  • abnormal trophoblast layer morphology / MGI
  • abnormal extraembryonic mesoderm development / MGI
  • embryonic lethality, complete penetrance / MGI
  • abnormal amniotic cavity morphology / MGI
  • absent ectoplacental cavity / MGI
  • small proamniotic cavity / MGI
  • absent extraembryonic coelom / MGI
  • small amniotic cavity / MGI
  • embryonic-extraembryonic boundary constriction / MGI

Literature references

  • Disruption of the talin gene arrests mouse development at the gastrulation stage.;Monkley S J, Zhou X H, Kinston S J, Giblett S M, Hemmings L, Priddle H, Brown J E, Pritchard C A, Critchley D R, Fässler R, ;2000;Developmental dynamics : an official publication of the American Association of Anatomists;219;560-74; 11084655

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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