B6.129P2-Tg(EEF1A1-Socs6)1Pwg/H
Status | Available to order |
EMMA ID | EM:01735 |
International strain name | B6.129P2-Tg(EEF1A1-Socs6)1Pwg/H |
Alternative name | Socs-6 (transgenic) |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(EEF1A1-Socs6)1Pwg, |
Gene/Transgene symbol | Tg(EEF1A1-Socs6)1Pwg |
Information from provider
Provider | Dr Ping Wang |
Provider affiliation | Cell and Molecular Biology, Karolinska Institutet |
Phenotypic information | 10% increase in body weight and increased insulin sensitivity. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.;Li Li, Grønning Line M, Anderson Per O, Li Suling, Edvardsen Klaus, Johnston Jim, Kioussis Dimitris, Shepherd Peter R, Wang Ping, ;2004;The Journal of biological chemistry;279;34107-14; 15123678
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