C57BL/6N-Tubg1tm1Ics/Ics

Status

Available to order

EMMA IDEM:15627
International strain nameC57BL/6N-Tubg1tm1Ics/Ics
Alternative nameTubg1tm1(Y92C)Ics (G4583)
Strain typeTargeted Mutant Strains : Point mutation
Allele/Transgene symbolTubg1tm1Ics
Gene/Transgene symbolTubg1

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis line was obtained by modification of TB1 in house derived C57BL/6N embryonic stem cells. Exon 2 (ENSMUSE00000970617) and 3 (ENSMUSE00000989844) were floxed and a point mutation (TAC to TGC) corresponding to the Y92C mutation was introduced in exon 3. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
lethal

Heterozygous:
DOI: 10.3390/biomedicines10123148 and DOI: 10.1038/s41467-019-10081-8
Breeding historyInbred C57BL/6N
References
  • TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.;Ivanova Ekaterina L, Gilet Johan G, Sulimenko Vadym, Duchon Arnaud, Rudolf Gabrielle, Runge Karen, Collins Stephan C, Asselin Laure, Broix Loic, Drouot Nathalie, Tilly Peggy, Nusbaum Patrick, Vincent Alexandre, Magnant William, Skory Valerie, Birling Marie-Christine, Pavlovic Guillaume, Godin Juliette D, Yalcin Binnaz, Hérault Yann, Dráber Pavel, Chelly Jamel, Hinckelmann Maria-Victoria, ;2019;Nature communications;10;2129; 31086189
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Literature references

  • TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.;Ivanova Ekaterina L, Gilet Johan G, Sulimenko Vadym, Duchon Arnaud, Rudolf Gabrielle, Runge Karen, Collins Stephan C, Asselin Laure, Broix Loic, Drouot Nathalie, Tilly Peggy, Nusbaum Patrick, Vincent Alexandre, Magnant William, Skory Valerie, Birling Marie-Christine, Pavlovic Guillaume, Godin Juliette D, Yalcin Binnaz, Hérault Yann, Dráber Pavel, Chelly Jamel, Hinckelmann Maria-Victoria, ;2019;Nature communications;10;2129; 31086189

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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