C57BL/6N-Tubb3tm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:15614 |
| International strain name | C57BL/6N-Tubb3tm1.1Ics/Ics |
| Alternative name | Tubb3tm1.1Ics (G5) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tubb3tm1.1Ics, |
| Gene/Transgene symbol | Tubb3 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This line was obtained by modification of BD10 in house derived C57BL/6N embryonic stem cells. The allele allows the expression of the wild-type Tubb3 protein first with a potential (cre recombinase-inducible) M388V point mutation. The flipped NeoR cassette was removed by breeding the male chimeras with flp recombinase deleter females. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:ViableHeterozygous:to be filled; see DOI: 10.3390/biomedicines10123148 |
| Breeding history | Inbred C57BL/6N |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904