- decreased rhombomere 3 size / MGI
STOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio Tg(Tbx21-AmCyan)Jfz/H
Status | Available to order |
EMMA ID | EM:15287 |
International strain name | STOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio Tg(Tbx21-AmCyan)Jfz/H |
Alternative name | AmCyanTbet-Egr3/2 double Knockout |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg-AmCyanTbet |
Gene/Transgene symbol | Tg-AmCyanTbet |
Information from provider
Provider | Suling Li |
Provider affiliation | Brunel University |
Genetic information | AmCyan-T-bet reporter mouse line (Yu et al., Nat. Immunol., 2015) crossed with a Egr3-/- and CD2-specific Egr2-/-(CD2-Egr2-/-;Egr3-/-) mice line, which was generated by interbreeding Egr3 KO (Tourtellotte and Milbrandt, Nat Genet 1998; MGI:2180063, symbol Egr3tm1Jmi) and CD2-specific Egr2 KO mice (Zhu et al., J Exp Med 2008; Li et al., Immunity 2012; Egr2-flox: MGI:2183227, symbol Egr2tm3Pch; CD2-Cre: MGI:2449947, symbol Tg(CD2-icre)4Kio). More than 30 backcrosses. |
Phenotypic information | Homozygous:The knock-out mice with deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with excessive serum proinflammatory cytokines but also impaired antigen receptor-induced proliferation of B and T cells.Heterozygous:Inflammation similar as homozygous but less severe. |
Breeding history | The AmCyan-T-bet reporter mouse line (Yu et al., 2015) was crossed with a Egr3-/- and CD2-specific Egr2-/- (CD2-Egr2-/-Egr3-/-) mice line, which was generated by interbreeding Egr3 knock-out (Tourtellotte and Milbrandt, 1998) and CD2-specific Egr2 knock-out mice (Zhu et al., J Exp Med 2008; Li et al., Immunity 2012). More than 30 backcrosses. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Dejerine-Sottas syndrome / Orphanet_64748
- Charcot-Marie-Tooth disease type 1D / Orphanet_101084
- Charcot-Marie-Tooth disease type 4E / Orphanet_99951
MGI phenotypes (allele matching)
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