FVB-Tg(Slc12a5*/luc)#Msa/Oulu
| Status | Available to order |
| EMMA ID | EM:14936 |
| International strain name | FVB-Tg(Slc12a5*/luc)#Msa/Oulu |
| Alternative name | KCC2(6.8mut)luc (=deltaNRSE) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Slc12a5*/luc)#Msa |
| Gene/Transgene symbol | Tg(Slc12a5*/luc)#Msa |
Information from provider
| Provider | Matti Airaksinen |
| Provider affiliation | Univ. Helsinki |
| Genetic information | The KCC2(6.8mut)luc is a transgenic luciferase reporter line with a genomic fragment of the Slc12a5 (KCC2) gene; similar to EMMA strain EM:14927 except for a 340bp (+355/+695) deletion in intron 1 that includes the neuron-restrictive silencer element (NRSE). The transgenic mice were produced by standard DNA pronucleus injection of fertilized FVB/N mouse strain oocytes. The transgenic strain was maintained in this background and has no obvious phenotype. |
| Phenotypic information | Homozygous:normalHeterozygous:normal |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous FVB/N |
Literature references
- Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene.;Uvarov Pavel, Pruunsild Priit, Timmusk Tõnis, Airaksinen Matti S, ;2005;Journal of neurochemistry;95;1144-55; 16271048