C57BL/6N-Kdm5bem2(IMPC)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:13527
International strain nameC57BL/6N-Kdm5bem2(IMPC)Wtsi/WtsiH
Alternative nameKdm5bem2(IMPC)Wtsi (VAAE)
Strain typeEndonuclease-mediated
Allele/Transgene symbolKdm5bem2(IMPC)Wtsi
Gene/Transgene symbolKdm5b

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationKdm5bem2(IMPC)Wtsi. Inverted exon KI, reverted to WT via loxP71/loxP66 inversion
Phenotypic informationHomozygous:
data not available

Heterozygous:
data not available
Breeding historyMosaic crossed with C57BL/6N then intercrossed
ReferencesNone available
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal recessive non-syndromic intellectual disability / Orphanet_88616
IMPC phenotypes (gene matching)
  • absent pinna reflex / IMPC
  • decreased body length / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal mammary gland development / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • reduced female fertility / MGI
  • female infertility / MGI
  • premature death / MGI
  • no phenotypic analysis / MGI
  • decreased uterus weight / MGI
  • decreased circulating estradiol level / MGI
  • slow postnatal weight gain / MGI
  • mortality/aging / MGI
  • neonatal lethality, incomplete penetrance / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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