IMPC phenotypes (gene matching)
C57BL/6NTac-Btktm1c(EUCOMM)Hmgu/IcsOrl
| Status | Available to order |
| EMMA ID | EM:13217 |
| International strain name | C57BL/6NTac-Btktm1c(EUCOMM)Hmgu/IcsOrl |
| Alternative name | C57BL/6NTac-Btk tm1c(EUCOMM)Hmgu/IcsOrl |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Btktm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Btk |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM-UAR44 |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0522_1_A11. For further details on the construction of this clone see the page at the IMPC portal. The tm1a mice have been crossed with flp recombinase-expressing mice (EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele. |
| Phenotypic information | Homozygous:Homozygous mice have not been generatedHeterozygous:Null |
| Breeding history | Rederived tm1a mice have been crossed with flp recombinase-expressing mice to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6N Tac |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia / Orphanet_632
- X-linked agammaglobulinemia / Orphanet_47
MGI phenotypes (gene matching)
- abnormal bone marrow cell number / MGI
- decreased neutrophil cell number / MGI
- spleen hypoplasia / MGI
- impaired myelopoiesis / MGI
- decreased IgM level / MGI
- autoimmune response / MGI
- abnormal B cell differentiation / MGI
- abnormal lymphopoiesis / MGI
- abnormal pre-B cell morphology / MGI
- abnormal macrophage physiology / MGI
- abnormal B cell physiology / MGI
- abnormal neutrophil physiology / MGI
- impaired neutrophil phagocytosis / MGI
- decreased IgD level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgE level / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased B cell number / MGI
- decreased acute inflammation / MGI
- decreased B cell proliferation / MGI
- abnormal B cell proliferation / MGI
- immune system phenotype / MGI
- decreased follicular B cell number / MGI
- increased pro-B cell number / MGI
- decreased transitional stage B cell number / MGI
- absent B-1a cells / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- abnormal B cell activation / MGI
- abnormal leukocyte morphology / MGI
- decreased spleen germinal center number / MGI
- decreased spleen germinal center size / MGI
- decreased IgG3 level / MGI
- abnormal lymph node germinal center morphology / MGI
- increased susceptibility to induced colitis / MGI
- decreased splenocyte number / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI