B6Brd;B6N-Tyrc-Brd Spns2tm1a(KOMP)Wtsi/Wtsi


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International strain nameB6Brd;B6N-Tyrc-Brd Spns2tm1a(KOMP)Wtsi/Wtsi
Alternative nameEPD0090_5_B04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSpns2tm1a(KOMP)Wtsi,
Gene/Transgene symbolSpns2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0090_5_B04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreWellcome Trust Sanger Institute, Hinxton, United Kingdom
Animals used for archivinghomozygous 0

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal rib morphology / IMPC
  • increased monocyte cell number / IMPC
  • decreased leukocyte cell number / IMPC
  • increased granulocyte number / IMPC
  • abnormal cornea morphology / IMPC
  • corneal opacity / IMPC
  • abnormal iris morphology / IMPC
  • abnormal eye pigmentation / IMPC
  • abnormal eye morphology / IMPC
  • abnormal eye size / IMPC
  • abnormal eyelid aperture / IMPC
  • decreased B cell number / IMPC
  • decreased T cell number / IMPC
  • corneal vascularization / IMPC
  • increased hemoglobin content / IMPC
  • absent pinna reflex / IMPC
  • increased NK cell number / IMPC
  • decreased CD4-positive, alpha beta T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased mature B cell number / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased effector memory CD4-positive, alpha-beta T cell number / IMPC
MGI phenotypes (allele matching)
  • increased monocyte cell number / MGI
  • decreased leukocyte cell number / MGI
  • increased granulocyte number / MGI
  • microphthalmia / MGI
  • cataract / MGI
  • small lens / MGI
  • abnormal cornea morphology / MGI
  • increased incidence of corneal inflammation / MGI
  • corneal opacity / MGI
  • abnormal pupil morphology / MGI
  • abnormal iris morphology / MGI
  • abnormal eye pigmentation / MGI
  • abnormal retina morphology / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • increased susceptibility to bacterial infection / MGI
  • increased bone strength / MGI
  • abnormal iridocorneal angle / MGI
  • abnormal auditory brainstem response / MGI
  • decreased B-1 B cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • abnormal ciliary body morphology / MGI
  • eyelids fail to open / MGI
  • narrow eye opening / MGI
  • abnormal corneal stroma morphology / MGI
  • increased circulating bilirubin level / MGI
  • immune system phenotype / MGI
  • corneal vascularization / MGI
  • decreased circulating glucose level / MGI
  • absent pinna reflex / MGI
  • increased NK T cell number / MGI
  • increased NK cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased follicular B cell number / MGI
  • decreased mature B cell number / MGI
  • decreased IgG1 level / MGI
  • eye opacity / MGI
  • increased bone mineral content / MGI
  • abnormal behavior / MGI

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    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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    Legally binding conditions for the transfer

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