B6.Cg-Tg(KRT14-Lgals7)46Ijmfp/Cnbc
Status | Available to order |
EMMA ID | EM:10827 |
International strain name | B6.Cg-Tg(KRT14-Lgals7)46Ijmfp/Cnbc |
Alternative name | Tg-K14galectin7 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(KRT14-Lgals7)46Ijmfp |
Gene/Transgene symbol | Tg(KRT14-Lgals7)46Ijmfp |
Information from provider
Provider | francoise POIRIER |
Provider affiliation | UMR 7592 CNRS-Université Paris Diderot, Institut Jacques Monod |
Genetic information | As described in Gendronneau 2015, C57BL/6;DBA/2 oocytes were microinjected with a construct containing the rat galectin 7 cDNA placed downstream of the keratin14 (K14) promoter (Saitou et al., 1995). |
Phenotypic information | Homozygous:Normal lifespan, mild epidermis defects.Heterozygous:Normal lifespan, mild epidermis defects. |
Breeding history | Founder animals carrying the transgene were mated with C57BL/6 individuals and two independent K14-galectin 7 transgenic lines. The tg46 line was established after eight successive backcrosses on the C57BL/6 background. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous C57BL/6J |
Literature references
- Overexpression of galectin-7 in mouse epidermis leads to loss of cell junctions and defective skin repair.;Gendronneau Gaëlle, Sanii Sadaf, Dang Tien, Deshayes Frédérique, Delacour Delphine, Pichard Evelyne, Advedissian Tamara, Sidhu Sukhvinder S, Viguier Mireille, Magnaldo Thierry, Poirier Francoise, ;2015;PloS one;10;e0119031; 25741714
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